The feasibility of additional CD19-targeted cellular therapy in relapsed/refractory B-ALL with re-emergence of CD19 antigen after prior CD19-negative relapse

被引:2
|
作者
Agrawal, Vaibhav [1 ,2 ]
Salhotra, Amandeep [1 ,2 ]
Song, Joo [3 ]
Gu, Zhaohui [3 ,4 ]
Stein, Anthony S. [1 ,2 ]
Marcucci, Guido [1 ,2 ]
Forman, Stephen J. [1 ,2 ]
Pullarkat, Vinod [1 ,2 ]
Aldoss, Ibrahim [1 ,2 ,5 ]
机构
[1] City Hope Natl Med Ctr, Gehr Family Ctr Leukemia Res, Dept Hematol & Hematopoiet Cell Transplantat, Duarte, CA USA
[2] City Hope Natl Med Ctr, Dept Pathol, Duarte, CA USA
[3] Beckman Res Inst City Hope, Dept Computat & Quantitat Med, Duarte, CA USA
[4] Beckman Res Inst City Hope, Dept Syst Biol, Duarte, CA USA
[5] City Hope Natl Med Ctr, Gehr Family Ctr Leukemia Res, Dept Hematol & Hematopoiet Cell Transplantat, Duarte, CA 91010 USA
关键词
BLINATUMOMAB; RESISTANCE;
D O I
10.1002/ajh.26787
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
引用
收藏
页码:E38 / E40
页数:3
相关论文
共 50 条
  • [1] Clinicopathologic features of relapsed CD19(-) B-ALL in CD19-targeted immunotherapy: Biological insights into relapse and LILRB1 as a novel B-cell marker for CD19(-) B lymphoblasts
    Chen, Dong
    Fuda, Franklin
    Rosado, Flavia
    Saumell, Silvia
    John, Samuel
    Chen, Mingyi
    Koduru, Prasad
    Chen, Weina
    INTERNATIONAL JOURNAL OF LABORATORY HEMATOLOGY, 2024, 46 (03) : 503 - 509
  • [2] Clinicopathologic Features of Relapsed CD19(-) B-ALL in CD19-Targeted Immunotherapy: Insights Into Mechanism of Relapse and LILRB1 as a Novel B-cell Marker for CD19(-) B Lymphoblasts
    Chen, Dong
    Fuda, Franklin
    Rosado, Flavia
    Saumell, Silvia
    John, Samuel
    Koduru, Prasad
    Chen, Weina
    LABORATORY INVESTIGATION, 2022, 102 (SUPPL 1) : 930 - 930
  • [3] Clinicopathologic Features of Relapsed CD19(-) B-ALL in CD19-Targeted Immunotherapy: Insights Into Mechanism of Relapse and LILRB1 as a Novel B-cell Marker for CD19(-) B Lymphoblasts
    Chen, Dong
    Fuda, Franklin
    Rosado, Flavia
    Saumell, Silvia
    John, Samuel
    Koduru, Prasad
    Chen, Weina
    MODERN PATHOLOGY, 2022, 35 (SUPPL 2) : 930 - 930
  • [4] Humanized CD19 CAR-T cells in relapsed/refractory B-ALL patients who relapsed after or failed murine CD19 CART therapy
    An, Lihong
    Lin, Yuehui
    Deng, Biping
    Yin, Zhichao
    Zhao, Defeng
    Ling, Zhuojun
    Wu, Tong
    Zhao, Yongqiang
    Chang, Alex H.
    Tong, Chunrong
    Liu, Shuangyou
    BMC CANCER, 2022, 22 (01)
  • [5] CD19 Negative Relapse in B-ALL Treated with Blinatumomab Therapy: Avoiding the Trap
    Yannakou, Costas K.
    Came, Neil
    Bajel, Ashish R.
    Juneja, Surender
    BLOOD, 2015, 126 (23)
  • [6] Frequent occurrence of CD19-negative relapse after CD19 CAR T and consolidation therapy in 14 TP53-mutated r/r B-ALL children
    Pan, Jing
    Tan, Yue
    Deng, Biping
    Tong, Chunrong
    Hua, Lin
    Ling, Zhuojun
    Song, Weiliang
    Xu, Jinlong
    Duan, Jiajia
    Wang, Zelin
    Guo, Huilin
    Yu, Xinjian
    Chang, Alex H.
    Zheng, Qinlong
    Feng, Xiaoming
    LEUKEMIA, 2020, 34 (12) : 3382 - 3387
  • [7] Incidence of CD19-negative relapse after CD19-targeted immunotherapy in R/R BCP acute lymphoblastic leukemia: a review
    Locatelli, Franco
    Shah, Bijal
    Thomas, Tracy
    Velasco, Kelly
    Adedokun, Babatunde
    Aldoss, Ibrahim
    Gore, Lia
    Hoelzer, Dieter
    Bassan, Renato
    Park, Jae H.
    Boissel, Nicolas
    Kantarjian, Hagop
    LEUKEMIA & LYMPHOMA, 2023, 64 (10) : 1615 - 1633
  • [8] Frequent occurrence of CD19-negative relapse after CD19 CAR T and consolidation therapy in 14 TP53-mutated r/r B-ALL children
    Jing Pan
    Yue Tan
    Biping Deng
    Chunrong Tong
    Lin Hua
    Zhuojun Ling
    Weiliang Song
    Jinlong Xu
    Jiajia Duan
    Zelin Wang
    Huilin Guo
    Xinjian Yu
    Alex H. Chang
    Qinlong Zheng
    Xiaoming Feng
    Leukemia, 2020, 34 : 3382 - 3387
  • [9] CD19 CAR-T Cell Therapy in Children with Relapsed and Refractory B-ALL
    Molostova, Olga
    Shelikhova, Larisa
    Muzalevsky, Yakov
    Kazachenok, Alexey
    Khismatullina, Rimma
    Abugova, Julia
    Kurnikova, Elena
    Trakhtman, Pavel
    Pershin, Dmitry
    Zubachenko, Viktoria
    Fadeeva, Maria
    Popov, Alexander M.
    Illarionova, Olga
    Miakova, Natalia
    Litvinov, Dmitry
    Novichkova, Galina
    Maschan, Alexey
    Maschan, Michael
    BLOOD, 2021, 138
  • [10] Novel Chimeric Antigen Receptor T Cells for the Treatment of CD19-Negative Relapses Occurring after CD19-Targeted Immunotherapies
    Ruella, Marco
    Barrett, David
    Kenderian, Saad S.
    Shestova, Olga
    Hofmann, Ted J.
    Scholler, John
    Lacey, Simon F.
    Melenhorst, Jan J.
    Nazimuddin, Farzana
    Kalos, Michael
    Porter, David L.
    June, Carl H.
    Grupp, Stephan A.
    Gill, Saar I.
    BLOOD, 2014, 124 (21)