Non-cytotoxic aza-BODIPY triterpene conjugates to target the endoplasmic reticulum

被引：1

作者：

Hoenke, Sophie ^{[1
]}

Brandes, Benjamin ^{[1
]}

Csuk, Rene ^{[1
]}

机构：

[1] Martin Luther Univ Halle Wittenberg, Organ Chem, Kurt Mothes Str 2, D-06120 Halle An Der Saale, Germany

来源：

EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY REPORTS | 2023年 / 7卷

关键词：

Triterpenes; aza BODIPY; Endoplasmic reticulum; Malignant cells; MITOCHONDRIA; DYES; NANOPARTICLES; RELEASE; DESIGN; PROBE;

D O I：

10.1016/j.ejmcr.2022.100099

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

In search of suitable tool to target the endoplasmic reticulum of human tumor cells, a non-cytotoxic aza-BODIPY derivative was designed and accessed in a simple synthesis in a few steps from commercially available starting materials. This aza-BODIPY was conjugated to 3-O-acetyl-triterpene carboxylic acids (glycyrrhetinic, ursolic, oleanolic, and betulinic acid) using a piperazinyl spacer. The resulting conjugates exhibited no cytotoxicity but were able to selectively target the ER.

引用

页数：8

共 11 条

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