The integration of two vertically crossed re-entrant honeycombs gives rise to a 3D re-entrant honeycomb (3DRH), which displays intricate three-dimensional auxeticity. To simplify the modeling complexity, this study employs asymptotic analysis of the energy functional stored in the unit cell of the 3D-RH to develop unified constitutive models for 3D structures and panels with multiple length scales. Based on this, an equivalent 3D Cauchy continuum model is established for multi -layer 3D-RH, while a 2D equivalent plate model is developed for sandwich panel with single -layer 3D-RH (SP-3D-RH). The accuracy and effectiveness of these equivalent models are subsequently confirmed through investigations of the X-shaped compressive deformation of multi -layer 3D-RH, as well as the in -plane auxetic deformation and out -of -plane dome -shaped deformation of single -layer 3D-RH. Compared to traditional hexagonal and re-entrant honeycomb sandwich panels, the SP-3D-RH exhibited enhanced equivalent tensile stiffness while effectively mitigating maximum deformation and strain energy under bending and tension conditions. However, due to its relatively low equivalent shear stiffness, the SP-3D-RH exhibited significant deformation and strain energy when subjected to torsional loads, resulting in local stress concentration in the connect region between adjacent facesheets. Parameter analysis shows that the facesheet-to-strut thickness ratio had a substantial impact on the equivalent stiffness and inplane behavior of the SP-3D-RH, while adjusting the horizontal strut length, strut depth, and re-entrant angle of the 3D-RH can improve the out -of -plane behavior.