The heterogeneity of tumor-associated macrophages and strategies to target it

被引:1
|
作者
La, Hao [1 ]
Zhu, Bo [1 ,2 ]
Chen, Degao [1 ,2 ]
机构
[1] Third Mil Med Univ, Xinqiao Hosp, Inst Canc, Chongqing 400037, Peoples R China
[2] Third Mil Med Univ, Xinqiao Hosp, Chongqing Key Lab Immunotherapy, Chongqing 400037, Peoples R China
基金
中国国家自然科学基金;
关键词
Tumor-associated macrophages; Tissue-resident macrophages; Heterogeneity; Immune checkpoint therapy; TISSUE-RESIDENT MACROPHAGES; MONOCLONAL-ANTIBODY; PANCREATIC-CANCER; CXCR4; INHIBITION; OPEN-LABEL; GM-CSF; MICROENVIRONMENT; BLOCKADE; CELLS; CCL2;
D O I
10.32604/biocell.2023.046367
中图分类号
Q [生物科学];
学科分类号
07 ; 0710 ; 09 ;
摘要
Tumor-associated macrophages (TAMs) are emerging as targets for tumor therapy because of their primary role in promoting tumor progression. Several studies have been conducted to target TAMs by reducing their infiltration, depleting their numbers, and reversing their phenotypes to suppress tumor progression, leading to the development of drugs in preclinical and clinical trials. However, the heterogeneous characteristics of TAMs, including their ontogenetic and functional heterogeneity, limit their targeting. Therefore, in-depth exploration of the heterogeneity of TAMs, combined with immune checkpoint therapy or other therapeutic modalities could improve the efficiency of tumor treatment. This review focuses on the heterogeneous ontogeny and function of TAMs, as well as the current development of tumor therapies targeting TAMs and combination strategies.
引用
收藏
页码:363 / 378
页数:16
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