Vedolizumab in Mild-to-Moderate Crohn's Disease Patients Naive to Biological Therapy: A Multicentric Observational Study

被引：1

作者：

Dotti, Adriana Zanoni ^{[1
,17
]}

Magro, Daniela Oliveira ^{[2
]}

Vilela, Eduardo Garcia ^{[3
]}

Chebli, Julio Maria Fonseca ^{[4
]}

Chebli, Liliana Andrade ^{[4
]}

Steinwurz, Flavio ^{[5
]}

Argollo, Marjorie ^{[6
]}

Carvalho, Nayara Salgado ^{[6
]}

Parente, Jose Miguel Luz ^{[7
]}

Lima, Murilo Moura ^{[7
]}

Parra, Rogerio Serafim ^{[8
]}

Perin, Ramir Luan ^{[9
]}

Flores, Cristina ^{[10
]}

Morsoletto, Eloa Marussi ^{[11
]}

Ferreira, Sandro da Costa ^{[8
]}

Ludvig, Juliano Coelho ^{[12
]}

Kaiser, Roberto Luiz ^{[13
]}

Faria, Mikaell Alexandre Gouvea ^{[13
]}

Nicollelli, Guilherme Mattioli

Andrade, Adriana Ribas ^{[14
]}

Queiroz, Natalia Sousa Freitas ^{[15
]}

Kotze, Paulo Gustavo ^{[16
]}

机构：

[1] UFPR, Hosp Clin, Curitiba, Brazil

[2] Univ Estadual Campinas UNICAMP, Campinas, Brazil

[3] Univ Fed Minas Gerais, Fac Med, Belo Horizonte, Brazil

[4] Univ Fed Juiz de Fora, Juiz De Fora, Brazil

[5] Hosp Israelita Albert Einstein, Sao Paulo, Brazil

[6] Hosp Sao Luiz Rede Dor, Sao Paulo, Brazil

[7] Univ Fed Piaui, Teresina, Brazil

[8] Univ Sao Paulo, Hosp Clin, Fac Med Ribeirao Preto, Sao Carlos, Brazil

[9] Univ Passo Fundo UPF, Passo Fundo, Brazil

[10] Inst Aparelho Digest IAD, Porto Alegre, Brazil

[11] Hosp Sao Vicente, Curitiba, Brazil

[12] Clin LUDVIG ESADI, Blumenau, Brazil

[13] Kaiser Clin, Sao Jose Do Rio Preto, SP, Brazil

[14] Univ Estado Bahia UNEB, Salvador, Brazil

[15] Hosp Santa Cruz, Curitiba, Brazil

[16] Pontificia Univ Catolica Parana PUCPR, Curitiba, Brazil

[17] UFPR, Hosp Clin, 181, St Gen Carneiro, Curitiba, PR, Brazil

来源：

CROHNS & COLITIS 360 | 2023年 / 5卷 / 04期

关键词：

Crohn disease; inflammatory bowel diseases; biological therapy; INFLAMMATORY-BOWEL-DISEASE; REAL-WORLD; INDUCTION;

D O I：

10.1093/crocol/otad053

中图分类号：

R57 [消化系及腹部疾病];

学科分类号：

摘要：

Background: In real-world experience, the number of patients using vedolizumab as first-line biological therapy was low. We aimed to evaluate the effectiveness and safety of vedolizumab in mild-to-moderate Crohn's disease (CD) biologic-naive patients.Methods: We performed a retrospective multicentric cohort study with patients who had clinical activity scores (Harvey-Bradshaw Index [HBI]) measured at baseline and weeks 12, 26, 52, as well as at the last follow-up. Clinical response was defined as a reduction >= 3 in HBI, whereas clinical remission as HBI <= 4. Mucosal healing was defined as the complete absence of ulcers in control colonoscopies. Kaplan-Meier survival analysis was used to assess the persistence with vedolizumab.Results: From a total of 66 patients, 53% (35/66) reached clinical remission at week 12. This percentage increased to 69.7% (46/66) at week 26, and 78.8% (52/66) at week 52. Mucosal healing was achieved in 62.3% (33/53) of patients. Vedolizumab was well tolerated, and most adverse events were minor. During vedolizumab treatment, 3/66 patients underwent surgery.Conclusions: This study demonstrates the effectiveness and safety of vedolizumab as a first-line biological agent in patients with mild-to-moderate CD.

引用

页数：8

共 50 条

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Vilela, E. G.
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