Haslea ostrearia Pigment Marennine Affects Key Actors of Neuroinflammation and Decreases Cell Migration in Murine Neuroglial Cell Model

被引:2
|
作者
Meresse, Sarah [1 ]
Gateau, Helene [2 ]
Tirnan, Tessa [1 ]
Larrigaldie, Vanessa [1 ]
Casse, Nathalie [2 ]
Pasetto, Pamela [3 ]
Mouget, Jean-Luc [2 ]
Mortaud, Stephane [1 ]
Fodil, Mostefa [2 ]
机构
[1] Univ Orleans, Immunol & Neurogenet Expt & Mol INEM, UMR CNRS 7355, F-45071 Orleans, France
[2] Le Mans Univ, Biol Organismes Stress St Environm BiOSSE, Ave Olivier Messiaen, F-72085 Le Mans, France
[3] Le Mans Univ, Inst Mol & Materiaux Mans, UMR CNRS 6283, Ave Olivier Messiaen, F-72085 Le Mans, France
基金
欧盟地平线“2020”;
关键词
diatoms; Haslea ostrearia; marennine; biomolecules; neuroglial cells; neuroinflammation; migration; immunostimulation; MICROGLIAL ACTIVATION; MOUSE MODEL; ASTROCYTES; EXPRESSION; SIMONSEN; IMMUNE; TNF;
D O I
10.3390/ijms24065388
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
Haslea ostrearia, a cosmopolitan marine pennate diatom, produces a characteristic blue pigment called marennine that causes the greening of filter-feeding organisms, such as oysters. Previous studies evidenced various biological activities of purified marennine extract, such as antibacterial, antioxidant and antiproliferative effects. These effects could be beneficial to human health. However, the specific biological activity of marennine remains to be characterized, especially regarding primary cultures of mammals. In the present study, we aimed to determine in vitro the effects of a purified extract of marennine on neuroinflammatory and cell migratory processes. These effects were assessed at non-cytotoxic concentrations of 10 and 50 mu g/mL on primary cultures of neuroglial cells. Marennine strongly interacts with neuroinflammatory processes in the immunocompetent cells of the central nervous system, represented by astrocytes and microglial cells. An anti-migratory activity based on a neurospheres migration assay has also been observed. These results encourage further study of Haslea blue pigment effects, particularly the identification of molecular and cellular targets affected by marennine, and strengthen previous studies suggesting that marennine has bioactivities which could be beneficial for human health applications.
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页数:16
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