Synthesis and Properties of N,N′-Disubstituted Ureas Containing Adamantane and Pyridine (Quinoline) Fragments

被引：3

作者：

Baykova, S. O. ^{[1
]}

Baykov, S. V. ^{[1
]}

Petrov, A. A. ^{[1
]}

Burmistrov, V. V. ^{[2
]}

Boyarskiy, V. P. ^{[1
]}

机构：

[1] St Petersburg State Univ, St Petersburg 199034, Russia

[2] Volgograd State Tech Univ, Volgograd 400005, Russia

来源：

RUSSIAN JOURNAL OF ORGANIC CHEMISTRY | 2023年 / 59卷 / 07期

关键词：

N-hetarylureas; adamantane; latent isocyanates; soluble epoxide hydrolase; SOLUBLE EPOXIDE HYDROLASE; INHIBITOR;

D O I：

10.1134/S1070428023070059

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

A series of N,N ' -disubstituted ureas containing a pyridine or quinoline fragment and a lipophilic adamantane moiety (13 examples, 53-94% yield) have been synthesized by the reaction of N,N-dimethyl-N '-(pyridin-2-yl or quinoline-2-yl)ureas with amine hydrochlorides. The synthesized compounds differed from each other by the position of substitution in the adamantane fragment, structure of the alkyl linker between the adamantane fragment and amide group, and heterocyclic substituent. They are potential target-oriented inhibitors of human soluble epoxide hydrolase (sEH).

引用

页码：1149 / 1157

页数：9

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[1] Synthesis and Properties of N,N′-Disubstituted Ureas Containing Adamantane and Pyridine (Quinoline) Fragments
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V. P. Boyarskiy
[J]. Russian Journal of Organic Chemistry, 2023, 59 : 1149 - 1157
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