Elucidating systemic immune responses to acute and convalescent SARS-CoV-2 infection in children and elderly individuals

被引：0

作者：

Rajamanickam, Anuradha ^{[1
,6
]}

Nathella, Pavan Kumar ^{[2
]}

Venkataraman, Aishwarya ^{[3
]}

Chandrasekaran, Padmapriyadarsini ^{[3
]}

Rajendraprasath, Sasidaran ^{[4
]}

Devaleenal, Bella D. ^{[3
]}

Pandiarajan, Arul Nancy ^{[1
]}

Krishnakumar, Gowshika ^{[4
]}

Ramanan, Padmasani Venkat ^{[4
]}

Babu, Subash ^{[1
,5
]}

机构：

[1] ICMR Natl Inst Res TB Int Ctr Excellence Res, Natl Inst Hlth, Chennai, India

[2] ICMR Natl Inst Res TB, Dept Immunol, Chennai, India

[3] ICMR Natl Inst Res TB, Dept Clin Res, Chennai, India

[4] Sri Ramachandra Inst Higher Educ & Res, Dept Radiol, Chennai, India

[5] NIAID, NIH, Lab Parasit Dis, Bethesda, MD USA

[6] NIH, Natl Inst Res TB, Int Ctr Excellence Res, Chennai, India

来源：

IMMUNITY INFLAMMATION AND DISEASE | 2024年 / 12卷 / 02期

关键词：

acute phase proteins; chemokines; children; complement components; COVID-19; cytokines; elderly; growth factors;

D O I：

10.1002/iid3.1167

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

BackgroundSevere Acute Respiratory Syndrome Coronavirus-2 (SARS-CoV-2), a causative pathogen of the COVID-19 pandemic, affects all age groups. However, various studies have shown that COVID-19 presentation and severity vary considerably with age. We, therefore, wanted to examine the differences between the immune responses of children with COVID-19 and elderly COVID-19 individuals.MethodsWe analyzed cytokines, chemokines, growth factors, and acute phase proteins in acute and convalescent COVID-19 children and the elderly with acute and convalescent COVID-19.ResultsWe show that most of the pro-inflammatory cytokines (interferon [IFN]gamma, interleukin [IL]-2, tumor necrosis factor-alpha [TNF alpha], IL-1 alpha, IFN alpha, IFN beta, IL-6, IL-12, IL-3, IL-7, IL-1Ra, IL-13, and IL-10), chemokines (CCL4, CCL11, CCL19, CXCL1, CXCL2, CXCL8, and CXL10), growth factors (vascular endothelial growth factor and CD40L) and acute phase proteins (C-reactive protein, serum amyloid P, and haptoglobin) were decreased in children with acute COVID 19 as compared with elderly individuals. In contrast, children with acute COVID-19 exhibited elevated levels of cytokines- IL-1 beta, IL-33, IL-4, IL-5, and IL-25, growth factors-fibroblast growth factor-2, platelet- derived growth factors-BB, and transforming growth factor alpha as compared with elderly individuals. Similar, differences were manifest in children and elderly with convalescent COVID-19.ConclusionThus, COVID-19 children are characterized by distinct cytokine/chemokine/growth factor/acute phase protein markers that are markedly different from elderly COVID-19 individuals. Children with COVID-19 are characterized by distinct cytokine/chemokine/growth factor/acute phase protein markers that are markedly different from elderly COVID-19 individuals. CRP, C-reactive protein; IFN, interferon; IL, interleukin; PCA, principal component analysis; TGF alpha, transforming growth factor alpha; TNF alpha, tumor necrosis factor alpha. image

引用

页数：11

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