Intravitreal Fluocinolone Acetonide Implant (ILUVIEN?) for the Treatment of Retinal Conditions. A Review of Clinical Studies

被引：7

作者：

Mushtaq, Yusuf ^{[1
,2
]}

Mushtaq, Maryam M. ^{[3
]}

Gatzioufas, Zisis ^{[4
,5
]}

Ripa, Matteo ^{[6
]}

Motta, Lorenzo ^{[7
,9
]}

Panos, Georgios D. ^{[1
,2
,8
]}

机构：

[1] Univ Nottingham, Nottingham Univ Hosp NHS Trust, Queens Med Ctr, Dept Ophthalmol, Nottingham, England

[2] Univ Nottingham, Sch Med, Nottingham, England

[3] Luton & Dunstable Univ Hosp NHS Trust, Dept Acute Med, Luton, England

[4] Basel Univ Hosp, Dept Ophthalmol, Basel, Switzerland

[5] Univ Basel, Sch Med, Basel, Switzerland

[6] Fdn Policlin Univ A Gemelli IRCCS, Ophthalmol Unit, Rome, Italy

[7] East Kent Hosp Univ NHS Fdn Trust, William Harvey Hosp, Dept Ophthalmol, Canterbury, Kent, England

[8] Queens Med Ctr, Dept Ophthalmol, Derby Rd, Nottingham NG7 2UH, England

[9] William Harvey Hosp, Dept Ophthalmol, Kennington Rd, Ashford TN24 0LZ, Kent, England

来源：

DRUG DESIGN DEVELOPMENT AND THERAPY | 2023年 / 17卷

关键词：

Iluvien; steroid implant; diabetic macular oedema; intravitreal implant; posterior uveitis; retinal vein occlusion; DIABETIC MACULAR EDEMA; LONG-TERM-BENEFIT; SUSTAINED-DELIVERY; NONINFECTIOUS INTERMEDIATE; AVAILABLE THERAPIES; VITREOUS INSERTS; EFFICACY; SAFETY; INJECTION; EYES;

D O I：

10.2147/DDDT.S403259

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

Fluocinolone acetonide (FAc) intravitreal implant (Iluvien (R)) is a corticosteroid implant indicated for the treatment of diabetic macular oedema (DMO) in patients who have previously received conventional treatment without good response, non- infectious posterior uveitis, and as an off-label treatment of the macular oedema secondary to retinal vein occlusion. FAc is a non -biodegradable 0.19 mg intravitreal implant which is designed to release FAc over 3 years at a rate of approximately 0.2 mcg per day. The aim of this review is to describe the special pharmacological properties of Iluvien and display the outcomes of the most important clinical trials and real-world studies regarding its efficacy and safety for the management of the above retinal disorders.

引用

页码：961 / 975

页数：15

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