Pirtobrutinib, a highly selective, non-covalent BTK inhibitor in Richter transformation: Results from the BRUIN study

被引：0

作者：

Lewis, David John ^{[1
]}

Wierda, William G. ^{[2
]}

Ghia, Paolo ^{[3
,4
]}

Shah, Nirav N. ^{[5
]}

Coombs, Catherine C. ^{[6
]}

Cheah, Chan Y. ^{[7
,8
]}

Lamanna, Nicole ^{[9
]}

Rhodes, Joanna M. ^{[10
]}

Hoffmann, Marc S. ^{[11
]}

Ma, Shuo ^{[12
]}

Eyre, Toby A. ^{[13
]}

Munir, Talha ^{[14
]}

Patel, Manish R. ^{[15
]}

Alencar, Alvaro J. ^{[16
]}

Tam, Constantine S. ^{[17
]}

Seymour, John F. ^{[17
]}

Jurczak, Wojciech ^{[18
]}

Lech-Maranda, Ewa ^{[19
]}

Roeker, Lindsey E. ^{[20
]}

Thompson, Philip A. ^{[2
]}

Abada, Paolo B. ^{[21
]}

Wang, Chunxiao ^{[22
]}

Nair, Binoj ^{[21
]}

Liu, Hui ^{[21
]}

Tsai, Donald E. ^{[21
]}

Mato, Anthony R. ^{[20
]}

机构：

[1] Plymouth Hosp NHS Trust, Derriford Hosp, Plymouth, Devon, England

[2] Univ Texas MD Anderson Canc Ctr, Houston, TX USA

[3] Univ Vita Salute San Raffaele, Milan, Italy

[4] IRCCS Osped San Raffaele, Milan, Italy

[5] Med Coll Wisconsin, Brookfield, WI USA

[6] Univ N Carolina, Chapel Hill, NC USA

[7] Linear Clin Res, Perth, Australia

[8] Sir Charles Gairdner Hosp, Perth, Australia

[9] Columbia Univ, Herbert Irving Comprehens Canc Ctr, New York Presbyterian, New York, NY USA

[10] Northwell Hlth Canc Inst, New Hyde Pk, NY USA

[11] Univ Kansas, Canc Ctr, Kansas City, MO USA

[12] Northwestern Univ, Feinberg Sch Med, Robert H Lurie Comprehens Canc Ctr, Chicago, IL USA

[13] Oxford Univ Hosp NHS Fdn Trust, Churchill Canc Ctr, Oxford, England

[14] St James Univ Hosp, Dept Haematol, Leeds, England

[15] Florida Canc Specialists, Sarah Cannon Res Inst, Sarasota, FL USA

[16] Univ Miami, Miller Sch Med, Sylvester Comprehens Canc Ctr, Miami, FL USA

[17] Univ Melbourne, Royal Melbourne Hosp, Peter MacCallum Canc Ctr, Melbourne, Australia

[18] Maria Sklodowska Curie Natl Res Inst Oncol, Krakow, Poland

[19] Inst Hematol & Transfus Med, Warsaw, Poland

[20] Mem Sloan Kettering Canc Ctr, New York, NY USA

[21] Loxo Lilly, Indianapolis, IN USA

[22] Eli Lilly & Co, Indianapolis, IN USA

来源：

BRITISH JOURNAL OF HAEMATOLOGY | 2023年 / 201卷

关键词：

D O I：

暂无

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

BSH23-PO80

引用

页码：107 / 108

页数：2

共 50 条

[1] Efficacy of Pirtobrutinib, a Highly Selective, Non-Covalent (Reversible) BTK Inhibitor in Richter Transformation: Results from the Phase 1/2 BRUIN Study
Wierda, William G.
Lewis, David John
Ghia, Paolo
Shah, Nirav N.
Coombs, Catherine C.
Cheah, Chan Y.
Lamanna, Nicole
Rhodes, Joanna M.
Hoffmann, Marc
Ma, Shuo
Eyre, Toby A.
Munir, Talha
Patel, Manish R.
Alencar, Alvaro J.
Tam, Constantine S.
Seymour, John F.
Jurczak, Wojciech
Lech-Maranda, Ewa
Roeker, Lindsey E.
Thompson, Philip A.
Abada, Paolo B.
Wang, Chunxiao
Nair, Binoj
Liu, Hui
Tsai, Donald E.
Mato, Anthony R.
[J]. BLOOD, 2022, 140
[2] Efficacy of pirtobrutinib, a highly selective, non-covalent (reversible) BTK inhibitor in Richter transformation: Results from the phase 1/2 BRUIN study
Rhodes, Joanna
Lewis, David
Ghia, Paolo
Shah, Nirav N.
Coombs, Catherine C.
Cheah, Chan Y.
Woyach, Jennifer
Lamanna, Nicole
Hoffmann, Marc S.
Ma, Shuo
Eyre, Toby A.
Munir, Talha
Patel, Manish R.
Alencar, Alvaro J.
Tam, Constantine S.
Seymour, John F.
Jurczak, Wojciech
Lech-Maranda, Ewa
Roeker, Lindsey E.
Thompson, Philip A.
Abada, Paolo B.
Wang, Chunxiao
Nair, Binoj
Liu, Hui
Tsai, Donald E.
Mato, Anthony R.
Wierda, William G.
[J]. CANCER RESEARCH, 2023, 83 (08)
[3] Pirtobrutinib, a Highly Selective, Non-Covalent (Reversible) BTK Inhibitor in Relapsed/Refractory Follicular Lymphoma: Results from the Phase 1/2 BRUIN Study
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[J]. BLOOD, 2023, 142
[4] Pirtobrutinib, A Highly Selective, Non-Covalent (Reversible) BTK Inhibitor in Previously Treated CLL/SLL: Updated Results from the Phase 1/2 BRUIN Study
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Woyach, Jennifer A.
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[J]. CLINICAL LYMPHOMA MYELOMA & LEUKEMIA, 2022, 22 : S268 - S269
[5] Pirtobrutinib, A Highly Selective, Non-covalent (Reversible) BTK Inhibitor In Previously Treated CLL/SLL: Updated Results From The Phase 1/2 BRUIN Study
Mato, Anthony
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Coombs, Catherine
Shah, Nirav
Lamanna, Nicole
Munir, Talha
Lech-Maranda, Ewa
Eyre, Toby
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Taylor, Justin
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Ghia, Paolo
Schuster, Stephen
Wang, Denise
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[J]. BRITISH JOURNAL OF HAEMATOLOGY, 2022, 197 : 97 - 101
[6] Efficacy of Pirtobrutinib, a Highly Selective, Non-Covalent (Reversible) BTK Inhibitor in Relapsed / Refractory Waldenstrom Macroglobulinemia: Results from the Phase 1/2 BRUIN Study
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Eyre, Toby A.
Jurczak, Wojciech
Lewis, David John
Gastinne, Thomas
Ma, Shuo
Cohen, Jonathon B.
Patel, Krish
Brown, Jennifer R.
Scarfo, Lydia
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Lech-Maranda, Ewa
Hoffmann, Marc
Ujjani, Chaitra S.
Fakhri, Bita
Wang, Michael L.
Izutsu, Koji
Nagai, Hirokazu
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Seymour, John F.
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Vose, Julie M.
McKinney, Matthew
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Koh, Youngil
Gao, Wei
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Cheah, Chan Y.
[J]. BLOOD, 2022, 140
[7] Pirtobrutinib, a Highly Selective, Non-Covalent (Reversible) BTK Inhibitor in Relapsed / Refractory Marginal Zone Lymphoma: Results from Phase 1/2 BRUIN Study
Patel, Krish
Vose, Julie M.
Nasta, Sunita D.
Brown, Jennifer R.
Maddocks, Kami J.
Woyach, Jennifer A.
Shah, Nirav N.
Fakhri, Bita
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Ma, Shuo
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Lech-Maranda, Ewa
Coombs, Catherine C.
Patel, Manish
Rhodes, Joanna M.
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Alencar, Alvaro J.
Cohen, Jonathon B.
Zelenetz, Andrew D.
Tsai, Donald E.
Li, Mei
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[J]. BLOOD, 2023, 142
[8] Pirtobrutinib, A Highly Selective, Non-covalent (Reversible) BTK Inhibitor In Previously Treated Mantle Cell Lymphoma: Updated Results From The Phase 1/2 BRUIN Study
Wang, Michael
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Pagel, John
Lamanna, Nicole
Cohen, Johnathon
Barve, Minal
Ghia, Paolo
Eyre, Toby
Zinzani, Pier Luigi
Ujjani, Chaitra
Koh, Youngil
Izutsu, Koji
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Tam, Constantine
Sundaram, Suchitra
Yin, Ming
Nair, Binoj
Tsai, Donald
Balbas, Minna
Mato, Anthony
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[J]. BRITISH JOURNAL OF HAEMATOLOGY, 2022, 197 : 101 - 104
[9] Pirtobrutinib; A Next Generation; Highly Selective; Non-covalent BTK Inhibitor In Previously Treated CLL/SLL: Updated Results From The Phase 1/2 BRUIN Study
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Lamanna, Nicole
Lech-Maranda, Ewa
Eyre, Toby A.
Woyach, Jennifer A.
Weirda, William G.
Cheah, Chan Y.
Roeker, Lindsey E.
Patel, Manish R.
Fakhri, Bita
Barve, Minal A.
Tam, Constantine
Lewis, David
Gerson, James N.
Alencar, Alvaro J.
Ghia, Paolo
Schuster, Stephen J.
Davids, Matthew S.
Brown, Jennifer R.
Jurczak, Wojciech
Mato, Anthony R.
[J]. ONCOLOGY RESEARCH AND TREATMENT, 2022, 45 (SUPPL 3) : 168 - 169
[10] Pirtobrutinib, A Next Generation, Highly Selective, Non-Covalent BTK Inhibitor in Previously Treated Mantle Cell Lymphoma: Updated Results from the Phase 1/2 BRUIN Study
Wang, Michael
Shah, Nirav N.
Alencar, Alvaro J.
Gerson, James N.
Patel, Manish R.
Fakhri, Bita
Jurczak, Wojciech
Tan, Xuan Ni
Lewis, Katharine
Fenske, Timothy S.
Coombs, Catherine C.
Flinn, Ian W.
Lewis, Davi John
Le Gouill, Steven
Palomba, M. Lia
Woyach, Jennifer A.
Pagel, John M.
Lamanna, Nicole
Cohen, Jonathon B.
Barve, Minal A.
Ghia, Paolo
Eyre, Toby A.
Zinzani, Pier Luigi Luigi
Ujjani, Chaitra S.
Koh, Youngil
Izutsu, Koji
Lech-Maranda, Ewa
Tam, Constantine S.
Sundaram, Suchitra
Yin, Ming
Nair, Binoj
Balbas, Minna
Tsai, Donald
Mato, Anthony R.
Cheah, Chan Yoon
[J]. BLOOD, 2021, 138

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