Recent advances in curcumin-loaded biomimetic nanomedicines for targeted therapies

被引：11
|
作者：
Lei, Fenting [1 ]
Li, Pei [1 ]
Chen, Tangting [2 ]
Wang, Qian [3 ]
Wang, Chenglong [4 ]
Liu, Yan [4 ]
Deng, Yiping [1 ]
Zhang, Zongquan [4 ]
Xu, Maochang [4 ]
Tian, Ji [1 ,8 ]
Ren, Wei [5 ,6 ,9 ]
Li, Chunhong [4 ,7 ]
机构：
[1] Southwest Med Univ, Anal & Testing Ctr, Sch Pharm, Luzhou 646000, Sichuan, Peoples R China
[2] Southwest Med Univ, Inst Cardiovasc Res, Key Lab Med Electrophysiol, Med Electrophysiol Key Lab Sichuan Prov,Minist Edu, Luzhou 646000, Sichuan, Peoples R China
[3] Southwest Med Univ, Coll Integrated Chinese & Western Med, Class Teaching & Res Dept, Affiliated Tradit Chinese Med Hosp, Luzhou 646000, Peoples R China
[4] Southwest Med Univ, Sch Pharm, Dept Pharmaceut Sci, Luzhou, Sichuan, Peoples R China
[5] Southwest Med Univ, Natl Tradit Chinese Med Clin Res Base & Drug Res C, Affiliated Tradit Chinese Med Hosp, Luzhou 646000, Peoples R China
[6] Southwest Med Univ, Inst Integrated Chinese & Western Med, Luzhou 646000, Peoples R China
[7] Southwest Med Univ, Sch Pharm, Dept Pharmaceut Sci, 1-1 Xianglin Rd, Luzhou 646000, Sichuan, Peoples R China
[8] Southwest Med Univ, Anal & Testing Ctr, Sch Pharm, 1-1 Xianglin Rd, Luzhou 646000, Sichuan, Peoples R China
[9] Southwest Med Univ, Inst Integrated Chinese & Western Med, 1-1 Xianglin Rd, Luzhou 646000, Sichuan, Peoples R China
来源：
JOURNAL OF DRUG DELIVERY SCIENCE AND TECHNOLOGY | 2023年 / 80卷
基金：
中国国家自然科学基金;
关键词：
Biomimetic nanomedicine; Curcumin; Cell membrane; Endogenous protein; Extracellular vesicles; HUMAN SERUM-ALBUMIN; MEMBRANE-CAMOUFLAGED NANOPARTICLES; DRUG-DELIVERY SYSTEM; IN-VITRO; ANTIINFLAMMATORY ACTIVITY; COATED NANOPARTICLES; ALZHEIMERS-DISEASE; BREAST-CANCER; CO-DELIVERY; EXOSOMES;
D O I：
10.1016/j.jddst.2023.104200
中图分类号：
R9 [药学];
学科分类号：
1007 ;
摘要：
Curcumin shows excellent anti-inflammatory and anti-tumor activities, but its solubility, stability, and bioavailability are poor. Nanoparticle delivery systems can be used to enhance physicochemical stability, water solubility and targeting. However, exogenous nanoparticles are easily removed by the immune system, so novel biomimetic nanomedicines delivery system with good biocompatibility, immunogenicity, and long circulation time need to be developed. This review summarizes the latest research on curcumin-loaded biomimetic nano -medicines prepared with cell membranes, extracellular vesicles, and endogenous proteins from animal cells, or prepared with extracellular vesicles from plants. The review aims to provide a theoretical basis for the devel-opment of biomimetic delivery systems from plants. With the study of the pharmacological properties of cur -cumin, more and more biomimetic materials have been applied and modified. Biomimetic nanoparticles show the advantages of reducing immunogenicity, increasing biocompatibility and targeting. The different classes of biomimetic nanoparticles have special advantages, and even more need to be combined to improve the devel-opment and utilization of curcumin.
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页数：13
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