Preclinical development of a next generation antibody drug conjugate (ADC) targeting B7-H3 for treatment of solid tumors

被引：1
|
作者：
Xu, Jian
Zong, Qing
Wang, Wei
Liu, Qigang
Stann, Sasha
Cai, Jiaqiang
机构：
来源：
CANCER RESEARCH | 2023年 / 83卷 / 07期
关键词：
D O I：
10.1158/1538-7445.AM2023-6304
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
6304
引用
收藏
页数：2
相关论文
共 50 条
  • [1] Preclinical development of a next generation antibody drug conjugate (ADC) targeting cMET for treatment of solid tumors
    Xiao, Liang
    Lian, Wei
    Song, Shuai
    Liu, Qigang
    Zong, Qing
    Stann, Sasha
    Cai, Jiaqiang
    Xue, Tongtong
    CANCER RESEARCH, 2024, 84 (06)
  • [2] Preclinical development of a duocarmycin-based antibody-drug conjugate targeting B7-H3 for solid cancer
    Son, Thomas
    Scribner, Juniper A.
    Hooley, Jeff
    Chiechi, Michael
    Li, Pam
    Hotaling, Timothy E.
    De Costa, Anushka
    Chen, Yan
    Chen, Francine
    Barat, Bhaswati
    Ciccarone, Valentina
    Gaynutdinov, Timur
    Tamura, James
    Koenig, Scott
    Johnson, Syd
    Moore, Paul A.
    Bonvini, Ezio
    Loo, Deryk
    CANCER RESEARCH, 2017, 77
  • [3] Testing of B7-H3 targeting antibody-drug conjugate (ADC) MGC018 in models of pediatric solid tumors by the Pediatric Preclinical Testing Consortium (PPTC).
    Kurmasheva, Raushan
    Mosse, Yael P.
    Del Pozo, Vanessa
    Earley, Eric J.
    Erickson, Stephen W.
    Groff, David
    Kolb, E. Anders
    Krytska, Kateryna
    Smith, Malcolm A.
    Tsang, Matthew
    Teicher, Beverly A.
    Gorlick, Richard Greg
    Maris, John M.
    Houghton, Peter
    JOURNAL OF CLINICAL ONCOLOGY, 2021, 39 (15)
  • [4] Preclinical development of MGC018, a duocarmycin-based antibody-drug conjugate targeting B7-H3 for solid cancer
    Scribner, Juniper A.
    Brown, Jennifer G.
    Sharma, Sharad
    Li, Hua
    Chiechi, Michael
    Li, Pam
    Son, Thomas
    De Costa, Anushka
    Chen, Yan
    Chen, Francine
    Barat, Bhaswati
    Huang, Ling
    Wolff, Christina
    Hooley, Jeff
    Hotaling, Tim E.
    Gaynutdinov, Timur
    Ciccarone, Valentina
    Tamura, James
    Koenig, Scott
    Johnson, Syd
    Moore, Paul A.
    Bonvini, Ezio
    Loo, Deryk
    CANCER RESEARCH, 2018, 78 (13)
  • [5] Preclinical Development of MGC018, a Duocarmycin-based Antibody-drug Conjugate Targeting B7-H3 for Solid Cancer
    Scribner, Juniper A.
    Brown, Jennifer G.
    Son, Thomas
    Chiechi, Michael
    Li, Pam
    Sharma, Sharad
    Li, Hua
    De Costa, Anushka
    Li, Ying
    Chen, Yan
    Easton, Ann
    Yee-Toy, Nicholas C.
    Chen, Francine Z.
    Gorlatov, Sergey
    Barat, Bhaswati
    Huang, Ling
    Wolff, Christina R.
    Hooley, Jeff
    Hotaling, Tim E.
    Gaynutdinov, Timur
    Ciccarone, Valentina
    Tamura, James
    Koenig, Scott
    Moore, Paul A.
    Bonvini, Ezio
    Loo, Deryk
    MOLECULAR CANCER THERAPEUTICS, 2020, 19 (11) : 2235 - 2244
  • [6] Development of a MMAE-based antibody-drug conjugate targeting B7-H3 for glioblastoma
    Mao, Yurong
    Wei, Ding
    Fu, Fengqing
    Wang, Huihui
    Sun, Ziyu
    Huang, Ziyi
    Wang, Yan
    Zhang, Guangbo
    Zhang, Xueguang
    Jiang, Biao
    Chen, Hongli
    EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 2023, 257
  • [7] B7-H3 is a potential antibody drug conjugate target for the treatment of prostate cancer
    Davies, Gareth C.
    Ryan, Kelli
    Smith, Alison J.
    Lloyd, Chris
    Tammali, Ravinder
    Monks, Noel
    Lewis, Arthur
    Wilkinson, Robert W.
    CANCER RESEARCH, 2018, 78 (13)
  • [8] Preclinical development of MGC026, a glycan-linked, exatecan-based antibodydrug conjugate (ADC) targeting B7-H3 for solid cancer
    Scribner, Juniper A.
    Brown, Jennifer G.
    Son, Thomas
    Jin, Linda
    McKenzie, Carroll
    Nam, Viktoriya
    Bush, Curtis
    Quinonez, Dienis
    Tamura, James
    Gorlatov, Sergey
    Li, Hua
    Butler, Shelley
    Bonvini, Ezio
    Loo, Deryk
    CANCER RESEARCH, 2024, 84 (06)
  • [9] ITC-6102RO, a novel B7-H3 antibody-drug conjugate, exhibits potent therapeutic effects against B7-H3 expressing solid tumors
    Shin, Seol Hwa
    Ju, Eun Jin
    Park, Jin
    Ko, Eun Jung
    Kwon, Mi Ri
    Lee, Hye Won
    Son, Ga Won
    Park, Yun-Yong
    Kim, Yeon Joo
    Song, Si Yeol
    Lee, Sangkwang
    Seo, Beom Seok
    Song, Jin-A
    Lim, Sangbin
    Jung, Doohwan
    Kim, Sunyoung
    Lee, Hyangsook
    Park, Seok Soon
    Jeong, Seong-Yun
    Choi, Eun Kyung
    CANCER CELL INTERNATIONAL, 2023, 23 (01)
  • [10] Preclinical development of a B7-H3-targeting ADC with a novel DNA topoisomerase I inhibitor for solid tumors
    Li, Chenggang
    Yao, Jun
    Qu, Chen
    Li, Bing
    Zhang, Yu
    Shi, Rong
    Qiu, Yang
    Hua, Haiqing
    CANCER RESEARCH, 2023, 83 (07)
12345