Recent antibacterial carbohydrate-based prodrugs, drugs and delivery systems to overcome antimicrobial resistance

被引：7
|
作者：
Maria, Catarina [1 ]
de Matos, Ana M. [1 ]
Rauter, Amelia P. [1 ]
机构：
[1] Univ Lisbon, Inst Mol Sci, Fac Ciencias, Ctr Quim Estrutural, P-1749016 Lisbon, Portugal
来源：
CURRENT OPINION IN CHEMICAL BIOLOGY | 2024年 / 78卷
关键词：
Antimicrobial resistance Drug development Carbohydrate-based; prodrugs Carbohydrate-based drugs Carbohydrate-based de-livery systems;
D O I：
10.1016/j.cbpa.2023.102419
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
Antimicrobial resistance is an increasing phenomenon that is threatening global health. Tuberculosis causative bacteria and several resistant and multidrug-resistant bacteria are widely spread and listed by the World Health Organization as global priorities for research and development. Hence, new antibacterial agents with new modes of action are urgently required. In this context, carbohydrate-based drugs have been extensively studied and used, presenting several benefits for therapeutical purposes. In this review, the latest efforts done in the carbohydrate-based antibacterial agents research field, reported from 2021 to 2023, are summarized. Carbohydratebased prodrugs, drugs, and delivery systems are covered, highlighting derivatization of existing antibiotics, use of nanotechnology, and repurposing of available therapeutical agents as the most popular strategies used in antibacterial agents' development.
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页数：8
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