miRNA-Based Technologies in Cancer Therapy

被引：7
|
作者：
Pagoni, Maria [1 ]
Cava, Claudia [2 ]
Sideris, Diamantis C. [3 ]
Avgeris, Margaritis [4 ]
Zoumpourlis, Vassilios [5 ]
Michalopoulos, Ioannis [6 ]
Drakoulis, Nikolaos [1 ]
机构：
[1] Natl & Kapodistrian Univ Athens, Fac Pharm, Sch Hlth Sci, Res Grp Clin Pharmacol & Pharmacogen, Athens 15701, Greece
[2] Univ Sch Adv Studies IUSS Pavia, Dept Sci Technol & Soc, I-27100 Pavia, Italy
[3] Natl & Kapodistrian Univ Athens, Fac Biol, Dept Biochem & Mol Biol, Athens 15701, Greece
[4] Natl & Kapodistrian Univ Athens, P&A Kyriakou Childrens Hosp, Dept Pediat 2, Lab Clin Biochem Mol Diagnost,Sch Med, Athens 11527, Greece
[5] Natl Hellen Res Fdn NHRF, Inst Chem Biol, Biomed Applicat Unit, Athens 11635, Greece
[6] Acad Athens, Biomed Res Fdn, Ctr Syst Biol, Athens 11527, Greece
来源：
JOURNAL OF PERSONALIZED MEDICINE | 2023年 / 13卷 / 11期
关键词：
miRNA; cancer; SEQUENCE-SPECIFIC INHIBITION; CELL-PROLIFERATION; SMALL RNAS; CIRCULATING MICRORNAS; NUCLEIC-ACID; HEXOKINASE; IN-VIVO; PHASE-I; ANTISENSE OLIGONUCLEOTIDES; REGULATES GLYCOLYSIS;
D O I：
10.3390/jpm13111586
中图分类号：
R19 [保健组织与事业（卫生事业管理）];
学科分类号：
摘要：
The discovery of therapeutic miRNAs is one of the most exciting challenges for pharmaceutical companies. Since the first miRNA was discovered in 1993, our knowledge of miRNA biology has grown considerably. Many studies have demonstrated that miRNA expression is dysregulated in many diseases, making them appealing tools for novel therapeutic approaches. This review aims to discuss miRNA biogenesis and function, as well as highlight strategies for delivering miRNA agents, presenting viral, non-viral, and exosomic delivery as therapeutic approaches for different cancer types. We also consider the therapeutic role of microRNA-mediated drug repurposing in cancer therapy.
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页数：29
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