Natural Compounds in Non-Melanoma Skin Cancer: Prevention and Treatment

被引：9
|
作者：
Kowalski, Szymon [1 ]
Karska, Julia [2 ]
Tota, Maciej [1 ]
Skinderowicz, Katarzyna [1 ]
Kulbacka, Julita [3 ,4 ]
Drag-Zalesinska, Malgorzata [5 ]
机构：
[1] Wroclaw Med Univ, Fac Med, Pasteura 1, PL-50367 Wroclaw, Poland
[2] Wroclaw Med Univ, Dept Psychiat, Pasteura 10, PL-50367 Wroclaw, Poland
[3] Wroclaw Med Univ, Fac Pharm, Dept Mol & Cellular Biol, Borowska 211A, PL-50556 Wroclaw, Poland
[4] State Res Inst Ctr Innovat Med, Dept Immunol & Bioelectrochem, Santariskiu 5, LT-08410 Vilnius, Lithuania
[5] Wroclaw Med Univ, Fac Med, Dept Human Morphol & Embryol, Div Histol & Embryol, T Chalubinskiego 6a, PL-50368 Wroclaw, Poland
来源：
MOLECULES | 2024年 / 29卷 / 03期
关键词：
natural compounds; natural agents; non-melanoma skin cancer; NMSC; SQUAMOUS-CELL CARCINOMA; ENDOPLASMIC-RETICULUM STRESS; HISTONE DEACETYLASE ACTIVITY; INGENOL MEBUTATE GEL; BASAL-CELL; ACTINIC KERATOSIS; VITAMIN-E; BETULINIC ACID; URSOLIC ACID; ENDOCANNABINOID SYSTEM;
D O I：
10.3390/molecules29030728
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
The elevated occurrence of non-melanoma skin cancer (NMSC) and the adverse effects associated with available treatments adversely impact the quality of life in multiple dimensions. In connection with this, there is a necessity for alternative approaches characterized by increased tolerance and lower side effects. Natural compounds could be employed due to their safety profile and effectiveness for inflammatory and neoplastic skin diseases. These anti-cancer drugs are often derived from natural sources such as marine, zoonotic, and botanical origins. Natural compounds should exhibit anti-carcinogenic actions through various pathways, influencing apoptosis potentiation, cell proliferation inhibition, and metastasis suppression. This review provides an overview of natural compounds used in cancer chemotherapies, chemoprevention, and promotion of skin regeneration, including polyphenolic compounds, flavonoids, vitamins, alkaloids, terpenoids, isothiocyanates, cannabinoids, carotenoids, and ceramides.
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页数：37
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