Substrate-Controlled Three-Component Synthesis of Diverse Fused Heterocycles

被引：3

作者：

Peshkov, Anatoly A. ^{[1
,2
]}

Gapanenok, Diana ^{[1
]}

Puzyk, Aleksandra ^{[1
]}

Amire, Niyaz ^{[2
]}

Novikov, Alexander S. ^{[1
,3
]}

Martynova, Sofia D. ^{[1
]}

Kalinin, Stanislav ^{[1
]}

Dar'in, Dmitry ^{[1
]}

Peshkov, Vsevolod A. ^{[2
]}

Krasavin, Mikhail ^{[1
,4
]}

机构：

[1] St Petersburg State Univ, Inst Chem, St Petersburg 199034, Russia

[2] Nazarbayev Univ, Sch Sci & Humanities, Dept Chem, Nur Sultan 010000, Kazakhstan

[3] Peoples Friendship Univ Russia, RUDN Univ, Res Inst Chem, Moscow 117198, Russia

[4] Immanuel Kant Balt Fed Univ, Kaliningrad 236016, Russia

来源：

JOURNAL OF ORGANIC CHEMISTRY | 2023年 / 88卷 / 15期

关键词：

CATALYST-FREE APPROACH; AZA-ENE REACTION; KETENE AMINALS; REGIOSELECTIVE SYNTHESIS; MULTICOMPONENT REACTIONS; CASCADE REACTION; C-C; DERIVATIVES; EFFICIENT; FACILE;

D O I：

10.1021/acs.joc.3c00497

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

A chemoselective strategy toward a variety of fused heterocyclicscaffolds relying on a three-component condensation of heterocyclicketene aminals (HKAs) or corresponding thioaminals with aryl glyoxalsand cyclic 1,3-dicarbonyl compounds has been developed and explored.Depending on the applied combination of substrates, the strategy canbe tuned to provide straightforward access to imidazo[1,2-a]quinoline, pyrrolo[1,2-a]imidazole, andpyrrolo[2,1-b]thiazole frameworks.

引用

页码：10508 / 10524

页数：17

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