CIZ1 in Xist seeded assemblies at the inactive X chromosome

被引：0

作者：

Sofi, Sajad ^{[1
]}

Coverley, Dawn ^{[1
,2
]}

机构：

[1] Univ York, Dept Biol, York, England

[2] Univ York, York Biomed Res Inst, York, England

来源：

FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY | 2023年 / 11卷

基金：

英国医学研究理事会;

关键词：

X inactivation; Xist (X-inactive specific transcript); CIZ1; phase separation; nuclear matrix; INTRINSICALLY DISORDERED REGIONS; REPLICATION FACTOR CIZ1; PHASE-SEPARATION; RNA; DNA; PROTEIN; GENE; DOMAINS; LNCRNA; IDENTIFICATION;

D O I：

10.3389/fcell.2023.1296600

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

There is growing evidence that X-chromosome inactivation is driven by phase-separated supramolecular assemblies. However, among the many proteins recruited to the inactive X chromosome by Xist long non-coding RNA, so far only a minority (CIZ1, CELF1, SPEN, TDP-43, MATR3, PTBP1, PCGF5) have been shown to form Xist-seeded protein assemblies, and of these most have not been analyzed in detail. With focus on CIZ1, here we describe 1) the contribution of intrinsically disordered regions in RNA-dependent protein assembly formation at the inactive X chromosome, and 2) enrichment, distribution, and function of proteins within Xist-seeded assemblies.

引用

页数：6

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