No rest for the wicked: Tumor cell senescence reshapes the immune microenvironment

被引：1
|
作者：
Hanna, Ann [1 ]
Balko, Justin M. [1 ,2 ,3 ]
机构：
[1] Vanderbilt Univ, Med Ctr, Dept Med, Nashville, TN 37232 USA
[2] Vanderbilt Univ, Med Ctr, Dept Pathol Microbiol & Immunol, Nashville, TN 37232 USA
[3] Vanderbilt Ingram Canc Ctr, Breast Canc Res Program, Nashville, TN 37232 USA
来源：
CANCER CELL | 2023年 / 41卷 / 05期
关键词：
D O I：
10.1016/j.ccell.2023.03.013
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
Senescence induces key phenotypic changes that can modulate immune responses. Four recent publications in Cancer Discovery, Nature, and Nature Cancer highlight how senescent cells (aged normal or chemotherapy-treated cells) express antigen presentation machinery, present antigens, and interact with T cells and dendritic cells to robustly activate the immune system and promote anti-tumor immunity.
引用
收藏
页码：831 / 833
页数：3
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