Emerging roles for G-quadruplexes in proteostasis

被引：7

作者：

Guzman, Bryan B. ^{[1
]}

Son, Ahyun ^{[2
]}

Litberg, Theodore J. ^{[2
]}

Huang, Zijue ^{[2
]}

Dominguez, Daniel ^{[1
]}

Horowitz, Scott ^{[2
]}

机构：

[1] Univ N Carolina, Dept Pharmacol, 120 Mason Farm Rd, Chapel Hill, NC 27599 USA

[2] Univ Denver, Knoebel Inst Hlth Aging, Dept Chem & Biochem, 2155 E Wesley Ave, Denver, CO 80208 USA

来源：

FEBS JOURNAL | 2023年 / 290卷 / 19期

关键词：

aggregation; ALS; Alzheimer; chaperone; fragile X; proteostasis; quadruplex; STRESS GRANULE FORMATION; PHASE-SEPARATION; PROTEIN INTERACTIONS; MESSENGER-RNAS; NUCLEIC-ACIDS; DNA-BINDING; IN-VITRO; DISEASE; AGGREGATION; REPEAT;

D O I：

10.1111/febs.16608

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

How nucleic acids interact with proteins, and how they affect protein folding, aggregation, and misfolding is a still-evolving area of research. Considerable effort is now focusing on a particular structure of RNA and DNA, G-quadruplexes, and their role in protein homeostasis and disease. In this state-of-the-art review, we track recent reports on how G-quadruplexes influence protein aggregation, proteolysis, phase separation, and protein misfolding diseases, and pose currently unanswered questions in the advance of this scientific field.

引用

页码：4614 / 4625

页数：12

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