First-in-human liver transplantation from a centenarian deceased donor after brain death

被引：4

作者：

De Simone, Paolo ^{[1
,2
]}

Ghinolfi, Davide ^{[1
]}

Palladino, Simona ^{[1
]}

Catalano, Gabriele ^{[1
]}

Martinelli, Caterina ^{[1
]}

Ducci, Juri ^{[1
]}

Bronzoni, Jessica ^{[1
]}

Tincani, Giovanni ^{[1
]}

Balzano, Emanuele ^{[1
]}

Carrai, Paola ^{[1
]}

Petruccelli, Stefania ^{[1
]}

Campani, Daniela ^{[2
,3
]}

Crocetti, Laura ^{[2
,4
]}

Lazzeri, Chiara ^{[6
]}

Biancofiore, Giandomenico ^{[2
,5
]}

Peris, Adriano ^{[7
]}

机构：

[1] Univ Pisa, Hepatobiliary Surg & Liver Transplantat, Med Sch Hosp, Via Paradisa 2, I-56124 Pisa, Italy

[2] Univ Pisa, Dept Surg Med Biochem Pathol & Intens Care, Pisa, Italy

[3] Univ Pisa, Dept Pathol, Med Sch Hosp, Pisa, Italy

[4] Univ Pisa, Intervent Radiol, Med Sch Hosp, Pisa, Italy

[5] Univ Pisa, Anesthesiol & Intens Care, Med Sch Hosp, Pisa, Italy

[6] Careggi Hosp, Reg Ctr Organ & Tissue Allocat, Florence, Italy

[7] Tuscany Reg Welf Minist, Org Toscana Trapianti, Florence, Italy

来源：

AMERICAN JOURNAL OF TRANSPLANTATION | 2024年 / 24卷 / 02期

关键词：

elderly donors; hepatocellular carcinoma; Immunotherapy; machine perfusion;

D O I：

10.1016/j.ajt.2023.09.014

中图分类号：

R61 [外科手术学];

学科分类号：

摘要：

Liver transplantation from elderly donors is expanding due to demand for liver grafts, aging of recipients and donors, and introduction of machine perfusion. We report on a liver transplant from a 100-year-old deceased donor after brain death. The liver was transplanted after the use of hypothermic machine perfusion to a 60-year-old recipient with advanced hepatocellular carcinoma undergoing neoadjuvant immunotherapy. Nine months after the transplant, the patient is alive with a functioning graft and no evidence of acute rejection or tumor recurrence.

引用

页码：304 / 307

页数：4

共 50 条

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De Simone, Paolo
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Palladino, Simona
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Martinelli, Caterina
Ducci, Juri
Bronzoni, Jessica
Tincani, Giovanni
Balzano, Emanuele
Carrai, Paola
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Campani, Daniela
Crocetti, Laura
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