Patient-centered digital biomarkers for allergic respiratory diseases and asthma: The ARIA-EAACI approach - ARIA-EAACI Task Force Report

被引：11

作者：

Bousquet, Jean ^{[1
,2
,3
,4
]}

Shamji, Mohamed H. ^{[5
,6
]}

Anto, Josep M. ^{[7
,8
,9
]}

Schuenemann, Holger J. ^{[10
]}

Canonica, G. Walter ^{[11
,12
]}

Jutel, Marek ^{[13
,14
]}

Del Giacco, Stefano ^{[15
,16
]}

Zuberbier, Torsten ^{[1
,2
,4
]}

Pfaar, Oliver ^{[17
]}

Fonseca, Joao A. ^{[18
,19
]}

Sousa-Pinto, Bernardo ^{[18
,19
]}

Klimek, Ludger ^{[20
,21
]}

Czarlewski, Wienczyslawa ^{[22
,23
]}

Bedbrook, Anna ^{[23
,24
]}

Amaral, Rita ^{[18
,19
]}

Ansotegui, Ignacio J. ^{[25
]}

Bosnic-Anticevich, Sinthia ^{[26
,27
,28
]}

Braido, Fulvio ^{[29
,30
]}

Chaves Loureiro, Claudia ^{[31
]}

Gemicioglu, Bilun ^{[32
]}

Haahtela, Tari ^{[33
]}

Kulus, Marek ^{[34
]}

Kuna, Piotr ^{[35
]}

Kupczyk, Maciej ^{[35
]}

Matricardi, Paolo M. ^{[36
]}

Regateiro, Frederico S. ^{[37
,38
,39
]}

Samolinski, Boleslaw ^{[40
]}

Sofiev, Mikhail ^{[41
]}

Toppila-Salmi, Sanna ^{[33
]}

Valiulis, Arunas ^{[42
,43
]}

Ventura, Maria Teresa ^{[44
,45
]}

Barbara, Cristina ^{[46
]}

Bergmann, Karl C. ^{[1
,2
,4
]}

Bewick, Michael ^{[47
]}

Blain, Hubert ^{[48
]}

Bonini, Matteo ^{[5
,49
,50
]}

Boulet, Louis-Philippe ^{[51
]}

Bourret, Rodolphe ^{[52
]}

Brusselle, Guy ^{[53
]}

Brussino, Luisa ^{[54
,55
]}

Buhl, Roland ^{[56
]}

Cardona, Victoria ^{[57
,58
]}

Casale, Thomas ^{[59
]}

Cecchi, Lorenzo ^{[60
]}

Charpin, Denis ^{[61
]}

Cherrez-Ojeda, Ivan ^{[62
,63
]}

Chu, Derek K.

Cingi, Cemal ^{[64
]}

Costa, Elisio M. ^{[65
,66
]}

Cruz, Alvaro A. ^{[67
,68
]}

机构：

[1] Free Univ Berlin, Charite Univ Med Berlin, Inst Allergol, Berlin, Germany

[2] Humboldt Univ, Berlin, Germany

[3] Univ Hosp Montpellier, Montpellier, France

[4] Fraunhofer Inst Translat Med & Pharmacol ITMP, Allergol & Immunol, Berlin, Germany

[5] Imperial Coll London, NHLI, London, England

[6] NIHR Imperial Biomed Res Ctr, London, England

[7] Barcelona Inst Global Hlth, ISGlobal, Barcelona, Spain

[8] UPF, Barcelona, Spain

[9] CIBER Epidemiol & Salud Publ CIBERESP, Barcelona, Spain

[10] McMaster Univ, Dept Hlth Res Methods Evidence & Impact, Dept Med, Hamilton, ON, Canada

[11] Humanitas Univ, Dept Biomed Sci, Milan, Italy

[12] IRCCS Humanitas Res Ctr, Personalized Med Asthma & Allergy, Milan, Italy

[13] Wroclaw Med Univ, Dept Clin Immunol, Wroclaw, Poland

[14] ALL MED Med Res Inst, Wroclaw, Poland

[15] Univ Cagliari, Univ Hosp Duilio Casula, Dept Med Sci & Publ Hlth, Cagliari, Italy

[16] Univ Cagliari, Univ Hosp Duilio Casula, Unit Allergy & Clin Immunol, Cagliari, Italy

[17] Univ Hosp Marburg, Dept Otorhinolaryngol Head & Neck Surg, Sect Rhinol & Allergy, Marburg, Germany

[18] Univ Porto, MEDCIDS Dept Community Med Informat & Hlth Decis, Fac Med, Porto, Portugal

[19] Univ Porto, CINTESIS RISE Hlth Res Network, Fac Med, Porto, Portugal

[20] Univ Med Mainz, Dept Otolaryngol Head & Neck Surg, Mainz, Germany

[21] Ctr Rhinol & Allergol, Wiesbaden, Germany

[22] Med Consulting Czarlewski, Levallois Perret, France

[23] MASK Air, Montpellier, France

[24] ARIA, Montpellier, France

[25] Hosp Quironsalud Bizkaia, Dept Allergy & Immunol, Bilbao, Spain

[26] Woolcock Inst Med Res, Qual Use Resp Med Grp, Sydney, NSW, Australia

[27] Sydney Local Hlth Dist, Sydney, NSW, Australia

[28] Univ Sydney, Sydney Pharm Sch, Sydney, NSW, Australia

[29] Univ Genoa, Dept Internal Med, Resp Clin, Genoa, Italy

[30] IRCCS Osped Policlin San Martino, Genoa, Italy

[31] Univ Coimbra, Hosp Univ Coimbra, Pneumol Unit, Ctr Hosp & Univ Coimbra, Coimbra, Portugal

[32] Istanbul Univ Cerrahpasa, Cerrahpasa Fac Med, Dept Pulm Dis, Istanbul, Turkiye

[33] Helsinki Univ Hosp, Univ Helsinki, Skin & Allergy Hosp, Helsinki, Finland

[34] Med Univ Warsaw, Dept Pediat Resp Dis & Allergol, Warsaw, Poland

[35] Med Univ Lodz, Barlicki Univ Hosp, Div Internal Med Asthma & Allergy, Lodz, Poland

[36] Charite Univ Med Berlin, Pediat Pulmonol Immunol & Intens Care Med, Berlin, Germany

[37] Ctr Hosp Univ Coimbra, Allergy & Clin Immunol Unit, Coimbra, Portugal

[38] Univ Coimbra, Coimbra Inst Clin & Biomed Res ICBR, Fac Med, Coimbra, Portugal

[39] Univ Coimbra, Inst Immunol, Fac Med, Coimbra, Portugal

[40] Med Univ Warsaw, Dept Prevent Environm Hazards Allergol & Immunol, Warsaw, Poland

[41] FMI, Helsinki, Finland

[42] Vilnius Univ, Inst Clin Med, Fac Med, Vilnius, Lithuania

[43] Vilnius Univ, Inst Hlth Sci, Fac Med, Vilnius, Lithuania

[44] Univ Bari, Sch Med, Unit Geriatr Immunoallergol, Bari, Italy

[45] Natl Res Council Ispa CNR, Inst Sci Food Prod, Bari, Italy

[46] Inst Saude Ambiental, Portuguese Natl Programme Resp Dis, Direcao Geral Saude, Fac Med Lisboa, Lisbon, Portugal

[47] Univ Cent Lancashire Med Sch, Preston, Lancs, England

[48] Montpellier Univ Hosp, Dept Geriatr, MUSE, Montpellier, France

[49] Univ Cattolica Sacro Cuore, Dept Cardiovasc & Resp Sci, Rome, Italy

[50] Fdn Policlin Univ Gemelli A IRCCS, Dept Neurol ENT & Thorac Sci, Rome, Italy

来源：

ALLERGY | 2023年 / 78卷 / 07期

基金：

欧盟地平线“2020”;

关键词：

apps; ARIA; digital health; EAACI; rhinitis; MOBILE TECHNOLOGY; WORK PRODUCTIVITY; PERSPECTIVE RAPP; RHINITIS CONTROL; AIR-POLLUTION; VALIDATION; QUESTIONNAIRE; RHINASTHMA; CARAT; UTILITY;

D O I：

10.1111/all.15740

中图分类号：

R392 [医学免疫学];

学科分类号：

100102 ;

摘要：

Biomarkers for the diagnosis, treatment and follow-up of patients with rhinitis and/or asthma are urgently needed. Although some biologic biomarkers exist in specialist care for asthma, they cannot be largely used in primary care. There are no validated biomarkers in rhinitis or allergen immunotherapy (AIT) that can be used in clinical practice. The digital transformation of health and health care (including mHealth) places the patient at the center of the health system and is likely to optimize the practice of allergy. Allergic Rhinitis and its Impact on Asthma (ARIA) and EAACI (European Academy of Allergy and Clinical Immunology) developed a Task Force aimed at proposing patient-reported outcome measures (PROMs) as digital biomarkers that can be easily used for different purposes in rhinitis and asthma. It first defined control digital biomarkers that should make a bridge between clinical practice, randomized controlled trials, observational real-life studies and allergen challenges. Using the MASK-air app as a model, a daily electronic combined symptom-medication score for allergic diseases (CSMS) or for asthma (e-DASTHMA), combined with a monthly control questionnaire, was embedded in a strategy similar to the diabetes approach for disease control. To mimic real-life, it secondly proposed quality-of-life digital biomarkers including daily EQ-5D visual analogue scales and the bi-weekly RhinAsthma Patient Perspective (RAAP). The potential implications for the management of allergic respiratory diseases were proposed.

引用

页码：1758 / 1776

页数：19

共 9 条

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