Effects of Metabolites of Lactobacillus casei on Expression and Neutralization of Shiga Toxin by Enterohemorrhagic Escherichia coli

被引：1
|
作者：
Aditya, Arpita [1 ]
Tabashsum, Zajeba [2 ]
Martinez, Zabdiel Alvarado [2 ]
Biswas, Debabrata [1 ,2 ,3 ]
机构：
[1] Univ Maryland, Dept Anim Sci, College Pk, MD 20742 USA
[2] Univ Maryland, Biol Sci Program, College Pk, MD 20742 USA
[3] Univ Maryland, Ctr Food Safety & Secur Syst, College Pk, MD 20742 USA
来源：
PROBIOTICS AND ANTIMICROBIAL PROTEINS | 2024年
基金：
美国食品与农业研究所;
关键词：
Shiga toxin; Metabolites; Conjugated linoleic acid; EHEC; Probiotics;
D O I：
10.1007/s12602-024-10212-8
中图分类号：
Q81 [生物工程学（生物技术）]; Q93 [微生物学];
学科分类号：
071005 ; 0836 ; 090102 ; 100705 ;
摘要：
Shiga toxin (stx), produced by enterohemorrhagic Escherichia coli (EHEC) or Shigella, causes hemolytic uremic syndrome (HUS) in humans. EHEC-mediated illnesses are recommended to treat by immune supportive strategies, instead of antibiotic therapy. Widely used probiotic Lactobacillus casei produces many bioactive metabolites, i.e., conjugated linoleic acids (CLAs) which have potential to educate host immunity and control EHEC growth and expression of its virulence genes. In this study, it was found that total metabolites of L. casei exerted a protective effect on Gb(3 )receptor containing mammalian cells against stx exposure.
引用
收藏
页数：7
相关论文
共 50 条
  • [1] Antagonistic Mechanism of Metabolites Produced by Lactobacillus casei on Lysis of Enterohemorrhagic Escherichia coli
    Aditya, Arpita
    Peng, Mengfei
    Young, Alana
    Biswas, Debabrata
    FRONTIERS IN MICROBIOLOGY, 2020, 11
  • [2] Oxidative Stress in Shiga Toxin Production by Enterohemorrhagic Escherichia coli
    Licznerska, Katarzyna
    Nejman-Falenczyk, Bozena
    Bloch, Sylwia
    Dydecka, Aleksandra
    Topka, Gracja
    Gasior, Tomasz
    Wegrzyn, Alicja
    Wegrzyn, Grzegorz
    OXIDATIVE MEDICINE AND CELLULAR LONGEVITY, 2016, 2016
  • [3] Antagonistic Effects of Conjugated Linoleic Acids of Lactobacillus casei against Foodborne Enterohemorrhagic Escherichia coli
    Aditya, Arpita
    Li, Yue
    Biswas, Debabrata
    JOURNAL OF FOOD PROTECTION, 2022, 85 (04) : 712 - 719
  • [4] Construction of a novel bioluminescent reporter system for investigating Shiga toxin expression of enterohemorrhagic Escherichia coli
    Shimizu, Takeshi
    Ohta, Yuko
    Tsutsuki, Hiroyasu
    Noda, Masatoshi
    GENE, 2011, 478 (1-2) : 1 - 10
  • [5] Transcriptional and Translational Inhibitors Block SOS Response and Shiga Toxin Expression in Enterohemorrhagic Escherichia coli
    Michael Berger
    Iqbal Aijaz
    Petya Berger
    Ulrich Dobrindt
    Gerald Koudelka
    Scientific Reports, 9
  • [6] Transcriptional and Translational Inhibitors Block SOS Response and Shiga Toxin Expression in Enterohemorrhagic Escherichia coli
    Berger, Michael
    Aijaz, Iqbal
    Berger, Petya
    Dobrindt, Ulrich
    Koudelka, Gerald
    SCIENTIFIC REPORTS, 2019, 9 (1)
  • [7] Probiotic Escherichia coli Nissle 1917 reduces growth, Shiga toxin expression, release and thus cytotoxicity of enterohemorrhagic Escherichia coli
    Mohsin, Mashkoor
    Guenther, Sebastian
    Schierack, Peter
    Tedin, Karsten
    Wieler, Lothar H.
    INTERNATIONAL JOURNAL OF MEDICAL MICROBIOLOGY, 2015, 305 (01) : 20 - 26
  • [8] Shiga toxin remodels the intestinal epithelial transcriptional response to Enterohemorrhagic Escherichia coli
    Warr, Alyson R.
    Kuehl, Carole J.
    Waldor, Matthew K.
    PLOS PATHOGENS, 2021, 17 (02)
  • [9] The human microbiota inhibits Shiga-toxin synthesis by enterohemorrhagic Escherichia coli
    de Sablet, Thibaut
    Chassard, Christophe
    Bernalier-Donadille, Annick
    Vareille, Marjolaine
    Gobert, Alain P.
    Martin, Christine
    GASTROENTEROLOGY, 2008, 134 (04) : A103 - A103
  • [10] Enterohemorrhagic strains of Escherichia coli (EHEC) and Shiga toxin-encoding bacteriophages
    Los, Joanna Monika
    Wegrzyn, Grzegorz
    POSTEPY MIKROBIOLOGII, 2011, 50 (03): : 175 - 190
12345