Polysciasoside B and C: new dammarane-type triterpene glycosides from the leaves of Australian rainforest plant Polyscias australiana (F.Muell.) Philipson (Araliaceae)

被引：0

作者：

Raju, Ritesh ^{[1
]}

Kumar, Paayal ^{[1
]}

Eladwy, Radwa A. ^{[2
]}

Bhuyan, Deep ^{[2
]}

Reddell, Paul ^{[3
]}

Munch, Gerald ^{[1
,2
]}

机构：

[1] Western Sydney Univ, Dept Pharmacol, Sydney, Australia

[2] Western Sydney Univ, NICM Hlth Res Inst, Penrith, Australia

[3] QBiot Grp Ltd, Yungaburra, Australia

来源：

NATURAL PRODUCT RESEARCH | 2024年 / 38卷 / 16期

关键词：

Cytotoxicity; dammarane; triterpene; polyscias australiana (F.Muell.) philipson; anti-inflammatory; araliaceae; OLEANANE SAPONINS;

D O I：

10.1080/14786419.2023.2241970

中图分类号：

O69 [应用化学];

学科分类号：

081704 ;

摘要：

Phytochemical investigation of the leaves of Polyscias australiana (F.Muell.) Philipson (family Araliaceae) led to the isolation and identification of two new analogues belonging to the rare dammarane-type triterpene glycosides, polysciasosides B (1) and C (2). Also isolated in high yields from this plant was the known saponin, & beta;-hedrin (3). The two new polysciasoside analogues exhibited no anti-inflammatory activity (inhibitory effects on NO inhibition and cell viability in RAW 264.7 macrophages) or cytotoxic activity against AGS gastric adenocarcinoma or the MCF7 breast adenocarcinoma cell lines. In contrast, the known compound & beta;-hedrin exhibited potent anti-inflammatory and cytotoxicity in these biological assays.

引用

页码：2836 / 2843

页数：8

共 3 条

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Yoshikawa, M
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Yoshikawa, M
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CHEMICAL & PHARMACEUTICAL BULLETIN, 1997, 45 (06) : 1056 - 1062
[3] Medicinal foodstuffs.: XXI.: Structures of new cucurbitane-type triterpene glycosides, goyaglycosides-a, -b, -c, -d, -e, -f, -g, and -h, and new oleanane-type triterpene saponins, goyasaponins I, II, and III, from the fresh fruit of Japanese Momordica charantia L.
Murakami, T
Emoto, A
Matsuda, H
Yoshikawa, M
CHEMICAL & PHARMACEUTICAL BULLETIN, 2001, 49 (01) : 54 - 63

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