Biomimetic nanomedicines for precise atherosclerosis theranostics

被引：8
|
作者：
Tao, Ying [1 ,2 ]
Lan, Xinmiao [3 ]
Zhang, Yang [4 ,5 ]
Fu, Chenxing [6 ,7 ]
Liu, Lu [8 ]
Cao, Feng [4 ,5 ]
Guo, Weisheng [1 ,2 ]
机构：
[1] Guangzhou Med Univ, Dept Minimally Invas Intervent Radiol, Key Lab Mol Target & Clin Pharmacol, Sch Biomed Engn, Guangzhou 510260, Peoples R China
[2] Guangzhou Med Univ, Affiliated Hosp 2, Guangzhou 510260, Peoples R China
[3] Capital Med Univ, Sch Pharmaceut Sci, Beijing 100069, Peoples R China
[4] Chinese Peoples Liberat Army Gen Hosp, Med Ctr 2, Dept Cardiol, Beijing 100853, Peoples R China
[5] Chinese Peoples Liberat Army Gen Hosp, Natl Clin Res Ctr Geriatr Dis, Beijing 100853, Peoples R China
[6] Southern Med Univ, Zhujiang Hosp, Dept Cardiol, Guangzhou 510280, Peoples R China
[7] Southern Med Univ, Zhujiang Hosp, Lab Heart Ctr, Guangzhou 510280, Peoples R China
[8] Univ Hong Kong, Li Ka Shing Fac Med, Dept Pharmacol & Pharm, Hong Kong 999077, Peoples R China
来源：
ACTA PHARMACEUTICA SINICA B | 2023年 / 13卷 / 11期
基金：
中国国家自然科学基金;
关键词：
Nanotheranostics; Atherosclerosis; Biomimetic nanomedicines; Drug delivery; Passive targeting; Active targeting; Plaques; Diagnosis and treatment; DRUG-DELIVERY; EXTRACELLULAR VESICLES; IN-VIVO; MEDIATED DELIVERY; TARGETED DELIVERY; MOUSE MODEL; NANOPARTICLES; PLAQUE; CELL; INFLAMMATION;
D O I：
10.1016/j.apsb.2022.11.014
中图分类号：
R9 [药学];
学科分类号：
1007 ;
摘要：
Atherosclerosis (AS) is a leading cause of the life-threatening cardiovascular disease (CVD), creating an urgent need for efficient, biocompatible therapeutics for diagnosis and treatment. Biomimetic nanomedicines (bNMs) are moving closer to fulfilling this need, pushing back the frontier of nano-based drug delivery systems design. This review seeks to outline how these nanomedicines (NMs) might work to diagnose and treat atherosclerosis, to trace the trajectory of their development to date and in the coming years, and to provide a foundation for further discussion about atherosclerotic theranostics.(c) 2023 Chinese Pharmaceutical Association and Institute of Materia Medica, Chinese Academy of Medical Sciences. Production and hosting by Elsevier B.V. This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).
引用
收藏
页码：4442 / 4460
页数：19
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