The hybrid manifold micro-pin-fin (MMPF) heat sink combined nozzle jets is an option for large-scale integrated circuits (LSI). The demond for uniform and ultra-high heat flux removal by MMPF heat sink has not been adequately investigated. This work aims to solve the problem of fluid organization. The proposed basic tiling topologies, including square, regular hexagon, 30 degrees rhombus, and 60 degrees rhombus topologies, provide different organized fluid flows and heat transfer patterns. The present study focuses on comparing these topologies according to independent porous medium parameters, such as nozzle pore size DZ, flow pore size DX,Y, and porosity epsilon. The results show that the square topology achieves the smallest total thermal resistance Rtot value of 0.0975 x 10-4 K m2/W, while the hexagon topology achieved the highest value of COP/Delta T, which was 2033.9 K-1. According to the sensitivity analysis results, the optimal total thermal resistance can be obtained by balancing the influences of nozzle pore size, flow pore size, and porosity. The optimal pressure drop can be obtained by maximizing the porosity.