Case report: Radiographic complete response of radiation-induced glioblastoma to front-line radiotherapy: A report and molecular characterization of two unique cases

被引:2
|
作者
Grogan, Patrick T. [1 ,2 ,3 ]
Helgager, Jeffrey J. [4 ]
Deming, Dustin A. [1 ,2 ,3 ]
Howard, Steven P. [3 ,5 ]
Jenkins, Robert B. [6 ]
Robins, H. Ian [1 ,3 ,5 ,7 ]
机构
[1] Univ Wisconsin, Dept Med, Div Hematol, Med Oncol & Palliat Care, Madison, WI 53211 USA
[2] Univ Wisconsin, Dept Oncol, McArdle Lab Canc Res, Madison, WI 53211 USA
[3] Univ Wisconsin, Carbone Comprehens Canc Ctr, Madison, WI 53211 USA
[4] Univ Wisconsin, Dept Pathol & Lab Med, Madison, WI USA
[5] Univ Wisconsin, Dept Human Oncol, Madison, WI USA
[6] Mayo Clin, Dept Lab Med & Pathol, Rochester, MN USA
[7] Univ Wisconsin, Dept Neurol, Madison, WI USA
来源
FRONTIERS IN NEUROLOGY | 2023年 / 14卷
关键词
radiation-induced glioma (RIG); complete response (CR); radiation; molecular sequencing; chromosomal microarray; CENTRAL-NERVOUS-SYSTEM; ADJUVANT TEMOZOLOMIDE; DNA-REPAIR; CONCOMITANT; SURVIVAL; GLIOMAS; CANCER;
D O I
10.3389/fneur.2023.1099424
中图分类号
R74 [神经病学与精神病学];
学科分类号
摘要
Radiation-induced gliomas (RIGs) are an uncommon disease type and a known long-term complication of prior central nervous system radiation exposure, often during childhood. Given the rarity of this malignancy subtype, no clinical trials have explored optimal therapy for these patients, and the literature is primarily limited to reports of patient cases and series. Indeed, the genomic profiles of RIGs have only recently been explored in limited numbers, categorizing these gliomas into a unique subset. Here, we describe two cases of RIG diagnosed as glioblastoma (GB), IDH-wildtype, in adults who had previously received central nervous system radiation for childhood cancers. Both patients demonstrated a surprising complete radiographic response of the postoperative residual disease to front-line therapy, a phenomenon rarely observed in the management of any GB and never previously reported for the radiation-induced subgroup. Both tumors were characterized by next-generation sequencing and chromosomal microarray to identify potential etiologies for this response as well as to further add to the limited literature about the unique molecular profile of RIGs, showing signatures more consistent with diffuse pediatric-type high-grade glioma, H3-wildtype, and IDH-wildtype, WHO grade 4. Ultimately, we demonstrate that treatment utilizing a radiation-based regimen for GB in a previously radiated tissue can be highly successful despite historical limitations in the management of this disease.
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页数:8
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