Deletion of Luzp2 Does Not Cause Hearing Loss in Mice

被引：0
|
作者：
Cheng, Cheng [1 ,2 ]
Zhu, Guangjie [1 ,2 ]
Wang, Kaijian [3 ]
Bu, Chuan [4 ]
Li, Siyu [1 ]
Qiu, Yue [1 ]
Lu, Jie [5 ]
Ji, Xinya [5 ]
Hao, Wenli [1 ]
Wang, Junguo [1 ,2 ]
Zhu, Chengwen [1 ,2 ]
Yang, Ye [1 ,2 ]
Gu, Yajun [1 ]
Qian, Xiaoyun [1 ,2 ]
Yu, Chenjie [1 ,2 ]
Gao, Xia [1 ,2 ]
机构：
[1] Nanjing Univ, Dept Otolaryngol Head & Neck Surg, Drum Tower Hosp,Affiliated Hosp, Med Sch,Jiangsu Prov Key Med Discipline Lab, Nanjing 210008, Peoples R China
[2] Res Inst Otolaryngol, Nanjing 210008, Peoples R China
[3] Nantong Univ, Affiliated Qidong Hosp, Qidong Liver Canc Inst, Dept Otorhinolaryngol,Qidong Peoples Hosp, Nantong 226200, Peoples R China
[4] Nanjing Med Univ, Affiliated Hosp 1, Kangda Coll, Peoples Hosp Lianyungang 1, Lianyungang 222000, Peoples R China
[5] Yangzhou Univ, Northern Jiangsu Peoples Hosp, Yangzhou 225001, Jiangsu, Peoples R China
来源：
NEUROSCIENCE BULLETIN | 2024年 / 40卷 / 10期
基金：
中国国家自然科学基金; 中国博士后科学基金;
关键词：
Hearing loss; Luzp2; Hair cell; Stereocilia; Ribbon synapse; LEUCINE-ZIPPER PROTEIN; INNERVATION; EXPRESSION; CELLS; MOTIF;
D O I：
10.1007/s12264-024-01202-5
中图分类号：
Q189 [神经科学];
学科分类号：
071006 ;
摘要：
Deafness is the prevailing sensory impairment among humans, impacting every aspect of one's existence. Half of congenital deafness cases are attributed to genetic factors. Studies have shown that Luzp2 is expressed in hair cells (HCs) and supporting cells of the inner ear, but its specific role in hearing remains unclear. To determine the importance of Luzp2 in auditory function, we generated mice deficient in Luzp2. Our results revealed that Luzp2 has predominant expression within the HCs and pillar cells. However, the loss of Luzp2 did not result in any changes in auditory threshold. HCs or synapse number and HC stereocilia morphology in Luzp2 knockout mice did not show any notable distinctions. This was the first study of the role of Luzp2 in hearing in mice, and our results provide important guidance for the screening of deafness genes.
引用
收藏
页码：1519 / 1528
页数：10
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