Catalyst- and solvent-free regioselective ring opening of aziridines with amines: application in the gram-scale synthesis of the α,β-diamino propionic derivative, aspergillomarasmine A

被引：2

作者：

Lin, Xing ^{[1
]}

Zhang, Dajun ^{[1
]}

Li, Jing ^{[1
]}

Zhang, Lei ^{[1
]}

机构：

[1] South China Univ Technol, Sch Biol & Biol Engn, Guangzhou 510006, Peoples R China

来源：

ORGANIC & BIOMOLECULAR CHEMISTRY | 2023年 / 21卷 / 24期

关键词：

ORTHOGONALLY PROTECTED AZALANTHIONINES; BETA-CYCLODEXTRIN; POTASSIUM THIOCYANATE; N-TOSYLAZIRIDINES; FLUORESCENT-PROBE; EFFICIENT; WATER; INHIBITOR; EPOXIDES; THIOLS;

D O I：

10.1039/d3ob00722g

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

A green and efficient approach for synthesizing alpha,beta-diamino propionic derivatives was developed through the ring opening of alpha-C-alkyloxycarbonyl aziridine. This method features catalyst- and solvent-free conditions, high regioselectivity, and wide substrate scope including solid amines, and realizes the gram-scale synthesis of aspergillomarasmine A.

引用

页码：4977 / 4981

页数：5

共 35 条

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