Dual-targeted CAR-NK cell therapy: optimized CAR design to prevent antigen escape and elicit a deep and durable response in multiple myeloma

被引:2
|
作者
Yang, Cuiqing
Wang, Yifang
Liu, Tingting
Wang, Chao
Wang, Huanyu
Wang, Qingyang
Wang, Qin
Ye, Gang
Tang, Renhong
Cao, Zhuoxiao
机构
关键词
D O I
10.1158/1538-7445.AM2023-4077
中图分类号
R73 [肿瘤学];
学科分类号
100214 ;
摘要
4077
引用
收藏
页数:2
相关论文
共 24 条
  • [1] FT576: Multi-Specific Off-the-Shelf CAR-NK Cell Therapy Engineered for Enhanced Persistence, Avoidance of Self-Fratricide and Optimized Mab Combination Therapy to Prevent Antigenic Escape and Elicit a Deep and Durable Response in Multiple Myeloma
    Goodridge, Jode P.
    Bjordahl, Ryan
    Mahmood, Sajid
    Reiser, John
    Gaidarova, Svetlana
    Blum, Robert
    Cichocki, Frank
    Chu, Hui-yi
    Bonello, Greg
    Lee, Tom
    Groff, Brian
    Meza, Miguel
    Chu, Yu-Waye
    Walcheck, Bruce
    Malmberg, Karl-Johan
    Miller, Jeffrey S.
    Rehm, Armin
    Hopken, Uta
    Valamehr, Bahram
    BLOOD, 2020, 136
  • [2] Chimeric antigen receptor natural killer (CAR-NK) cell design and engineering for cancer therapy
    Ying Gong
    Roel G. J. Klein Wolterink
    Jianxiang Wang
    Gerard M. J. Bos
    Wilfred T. V. Germeraad
    Journal of Hematology & Oncology, 14
  • [3] Chimeric antigen receptor natural killer (CAR-NK) cell design and engineering for cancer therapy
    Gong, Ying
    Klein Wolterink, Roel G. J.
    Wang, Jianxiang
    Bos, Gerard M. J.
    Germeraad, Wilfred T. V.
    JOURNAL OF HEMATOLOGY & ONCOLOGY, 2021, 14 (01)
  • [4] Defining an Optimal Dual-Targeted CAR T-cell Therapy Approach Simultaneously Targeting BCMA and GPRC5D to Prevent BCMA Escape-Driven Relapse in Multiple Myeloma
    de Larrea, Carlos Fernandez
    Staehr, Mette
    Lopez, Andrea, V
    Ng, Khong Y.
    Chen, Yunxin
    Godfrey, William D.
    Purdon, Terence J.
    Ponomarev, Vladimir
    Wendel, Hans-Guido
    Brentjens, Renier J.
    Smith, Eric L.
    BLOOD CANCER DISCOVERY, 2020, 1 (02): : 146 - 154
  • [5] Allogeneic CAR-NK Cell Therapy Targeting Both BCMA and GPRC5D for the Treatment of Multiple Myeloma
    Cao, Zhuoxiao
    Yang, Cuiqing
    Wang, Yifang
    Wang, Chao
    Wang, Qingyang
    Ye, Gang
    Liu, Tingting
    Wang, Qin
    Wang, Huanyu
    Gong, Yanxue
    Wang, Biye
    Jiang, Fuwei
    BLOOD, 2022, 140 : 7378 - 7378
  • [6] BCMA AND CD229 DUAL-TARGETED CAR T CELL EFFECTIVELY CONTROLS MULTIPLE MYELOMA WITH LOSS OF BCMA EXPRESSION
    Gerardo Rodriguez-Lobato, Luis
    Cardus, Oriol
    Battram, Joan Mane Anthony M.
    Perez-Amill, Lorena
    Calderon, Hugo
    Martin-Antonio, Beatriz
    Oliver-Caldes, Aina
    Lozano, Ester
    Moreno, David F.
    Ortiz-Maldonado, Valentin
    Queralt Salas, Maria
    de Daniel i Bisbe, Anna
    Tovar, Natalia
    Jimenez, Raquel
    Teresa Cibeira, M.
    Rosinol, Laura
    Blade, Joan
    Juan, Manel
    Urbano-Ispizua, Alvaro
    Engel, Pablo
    Fernandez de larrea, Carlos
    BONE MARROW TRANSPLANTATION, 2023, 58 (SUPP1) : 45 - 46
  • [7] Preclinical development of first-of-kind dual-targeted off-the-shelf CAR-NK cell product with engineered persistence for an effective treatment of B cell malignancies
    Goodridge, Jode
    Mahmood, Sajid
    Zhu, Huang
    Gaidarova, Svetlana
    Blum, Robert
    Bjordahl, Ryan
    Cichocki, Frank
    Chu, Hui-Yi
    Bonello, Greg
    Lee, Tom
    Groff, Brian
    Malmberg, Karl-Johan
    Walcheck, Bruce
    Miller, Jeffrey
    Kaufman, Dan
    Valamehr, Bahram
    CANCER RESEARCH, 2019, 79 (13)
  • [8] Optimal Dual-Targeted CAR Construct Simultaneously Targeting Bcma and GPRC5D Prevents Bcma-Escape Driven Relapse in Multiple Myeloma
    de Larrea, Carlos Fernandez
    Staehr, Mette
    Lopez, Andrea
    Chen, Yunxin
    Purdon, Terence J.
    Ng, Khong Y.
    Wendel, Hans
    Brentjens, Renier J.
    Smith, Eric L.
    BLOOD, 2019, 134
  • [9] Defining an Optimal Dual-Targeted CAR T-cell Therapy Approach Simultaneously Targeting BCMA and GPRC5D to Prevent BCMA Escape-Driven Relapse in Multiple Myeloma (vol 1, pg 146, 2020)
    de Larrea, C. Fernandez
    Staehr, M.
    Lopez, A., V
    Ng, K. Y.
    Chen, Y.
    Godfrey, W. D.
    BLOOD CANCER DISCOVERY, 2024, 5 (02): : 132 - 132
  • [10] Case report: Dual-targeted BCMA and CS1 CAR-T-cell immunotherapy in recurrent and refractory extramedullary multiple myeloma
    Shi, Xiangjun
    Wu, Yue
    Yao, Xingchen
    Du, Boran
    Du, Xinru
    FRONTIERS IN IMMUNOLOGY, 2024, 15