Impact of AJCC 8 pT staging in cutaneous head and neck squamous cell carcinoma in a nonselected real-world patient sample

被引：1
|
作者：
Girardi, Fabio Muradas [1 ]
Wagner, Vivian P. [2 ]
Martins, Manoela Domingues [3 ,4 ]
Abentroth, Aliende Lengler [1 ]
Hauth, Luiz Alberto [1 ]
机构：
[1] Integrated Oncol Ctr Ana Nery Hosp, Santa Cruz Do Sul, RS, Brazil
[2] Univ Sheffield, Acad Unit Oral & Maxillofacial Med & Pathol, Dept Clin Dent, Sheffield, S Yorkshire, England
[3] Univ Fed Rio Grande do Sul, Sch Dent, Dept Oral Pathol, Porto Alegre, RS, Brazil
[4] Porto Alegre Clin Hosp HCPA UFRGS, Dept Oral Med, Porto Alegre, RS, Brazil
来源：
HEAD AND NECK-JOURNAL FOR THE SCIENCES AND SPECIALTIES OF THE HEAD AND NECK | 2023年 / 45卷 / 02期
关键词：
neoplasm staging; skin neoplasms; squamous cell carcinoma of head and neck; RISK-FACTORS; 8TH EDITION; METASTASIS; RECURRENCE; MANAGEMENT;
D O I：
10.1002/hed.27233
中图分类号：
R76 [耳鼻咽喉科学];
学科分类号：
100213 ;
摘要：
Objective Our aim was to evaluate characteristics associated with worse survival and the effectiveness of AJCC 8 in a real-world cohort of HNCSCC from South Brazil. Methods A 10-year retrospective cohort study (2011-2020) at a tertiary care center comprising 647 HNCSCC excised from 435 patients. Results At multivariable analysis, ear/nose/zygomatic or periorbital site, compromised or exiguous margins, and advanced pT stage were independent factors associated to DFS, while age, pN, and loco-regional recurrence were independent factors associated to DSS. Cox-regression multivariable models showed that the pT stage was statistically significant for the DFS, but not DSS. A significant distinction was only observed between T1 and T2. Conclusion It was only in the lower categories of AJCC 8 (T1 and T2) that we were able to demonstrate the ability to stratify tumors with a significant risk of poor disease-related outcomes.
引用
收藏
页码：337 / 346
页数：10
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