Combination of Oncolytic Virotherapy with Different Antitumor Approaches against Glioblastoma

被引：1
|
作者：
Ageenko, Alisa [1 ]
Vasileva, Natalia [1 ,2 ]
Richter, Vladimir [1 ]
Kuligina, Elena [1 ,2 ]
机构：
[1] Russian Acad Sci, Inst Chem Biol & Fundamental Med, Siberian Branch, Akad Lavrentiev Ave 8, Novosibirsk 630090, Russia
[2] LLC Oncostar, R&D Dept, Ingenernaya St 23, Novosibirsk 630090, Russia
来源：
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES | 2024年 / 25卷 / 04期
基金：
俄罗斯科学基金会;
关键词：
glioblastoma; oncolytic viruses; chemotherapy; radiotherapy; immunotherapy; combination therapy; HERPES-SIMPLEX-VIRUS; MEASLES-VIRUS; MALIGNANT GLIOMA; VACCINIA VIRUS; RADIATION-THERAPY; MYXOMA VIRUS; PRECLINICAL EVALUATION; CANCER-CELLS; PHASE-I; GM-CSF;
D O I：
10.3390/ijms25042042
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
Glioblastoma is one of the most malignant and aggressive tumors of the central nervous system. Despite the standard therapy consisting of maximal surgical resection and chemo- and radiotherapy, the median survival of patients with this diagnosis is about 15 months. Oncolytic virus therapy is one of the promising areas for the treatment of malignant neoplasms. In this review, we have focused on emphasizing recent achievements in virotherapy, both as a monotherapy and in combination with other therapeutic schemes to improve survival rate and quality of life among patients with glioblastoma.
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页数：26
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