A New Monoterpene-Phenylpropanoid from Illicium difengpi

被引：1

作者：

Ning, Desheng ^{[1
]}

Fu, Yuxia ^{[1
]}

Li, Lianchun ^{[1
]}

Zou, Zhiqi ^{[1
,2
]}

Pan, Zhenghong ^{[1
]}

机构：

[1] Guangxi Zhuang Autonomous Reg & Chinese Acad Sci, Guangxi Inst Bot, Guangxi Key Lab Plant Funct Phytochemicals & Sust, Guilin, Guangxi, Peoples R China

[2] Guangxi Univ Chinese Med, Coll Pharm, Nanning 530200, Peoples R China

来源：

CHINESE JOURNAL OF ORGANIC CHEMISTRY | 2023年 / 43卷 / 04期

基金：

中国国家自然科学基金;

关键词：

Illicium difengpi; monoterpene-phenylpropanoid; structural identification; absolute configuration; NITRIC-OXIDE; SIGNALING PATHWAY;

D O I：

10.6023/cjoc202208033

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Four compounds were isolated from the dichloromethane extract of stem bark of Illicium difengpi by using various column chromatographic methods. Their structures were identified as difengpienol D (1), (E)-3,4-methylenedioxophenyl propenal (2), dihydrocubebin (3) and pestalotiopyrone G (4) respectively by mass spectrometry (MS), infrared spectroscopy (IR), nuclear magnetic resonance spectroscopy (NMR), etc. and quantum chemical calculation method. Compound 1 was an unusual new compound formed by acyclic monoterpenoid and phenylpropanoid through C-C chain, and was also the first monoterpene-phenylpropanoid isolated from the genus Illicium. It showed weak anti-inflammatory activity.

引用

页码：1591 / 1595

页数：5

共 18 条

[1] [Anonymous], 2004, EDITORIAL COMMITTEE, V30, P218
[2] Discovery of the nitric oxide signaling pathway and targets for drug development
Bryan, Nathan S.
Bian, Ka
Murad, Ferid
[J]. FRONTIERS IN BIOSCIENCE-LANDMARK, 2009, 14 : 1 - +
[3] Chines Pharmacopoeia Commission, 2020, PHARMACOPOEIA PEOPLE, V1, P128
[4] Nitric Oxide and Cyclic GMP Signaling Pathway as a Focus for Drug Development
Kots, A. Y.
Bian, K.
Murad, F.
[J]. CURRENT MEDICINAL CHEMISTRY, 2011, 18 (22) : 3299 - 3305
[5] MULTIFUNCTIONAL ROLE OF NITRIC-OXIDE IN INFLAMMATION
LASKIN, JD
HECK, DE
LASKIN, DL
[J]. TRENDS IN ENDOCRINOLOGY AND METABOLISM, 1994, 5 (09): : 377 - 382
[6] Structure elucidation and anti-inflammatory mechanism of difengpienol C, a new neolignan isolated from Illicium difengpi
Li, Lian-Chun
Ning, De-Sheng
Fu, Yu-Xia
Pan, Zheng-Hong
[J]. FITOTERAPIA, 2021, 153
[7] Nitric oxide and macrophage function
MacMicking, J
Xie, QW
Nathan, C
[J]. ANNUAL REVIEW OF IMMUNOLOGY, 1997, 15 : 323 - 350
[8] Difengpienols A and B, two new sesqui-neolignans with anti-inflammatory activity from the bark of Illicium difengpi
Pan, Zheng-Hong
Cheng, Ling
Ning, De-Sheng
Peng, Li-Yan
Fu, Yu-Xia
Li, Lian-Chun
[J]. PHYTOCHEMISTRY LETTERS, 2019, 30 : 210 - 214
[9] Lignan Glucosides from the Stem Barks of Illicium difengpi
Pan, Zheng-Hong
Ning, De-Sheng
Huang, Si-Si
Cheng, Ling
Xia, Meng-Wen
Peng, Li-Yan
Li, Dian-Peng
[J]. MOLECULES, 2016, 21 (05)
[10] Role of nitric oxide in inflammatory diseases
Sharma J.N.
Al-Omran A.
Parvathy S.S.
[J]. Inflammopharmacology, 2007, 15 (6) : 252 - 259

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