The Influence of Moringa Oleifera Leaf Extract on Periodontitis Cases Through Rankl Expression Analysis

Introduction: Periodontitis is a chronic inflammatory disease that causes damage to the supporting structures of the teeth, and if left untreated this disease will lead to impaired function, appearance, pain and loss of teeth. Periodontitis is caused by bacteria and growing on the tooth surface. The "red complex" bacteria consists of Porphyromonas gingivalis, Treponema denticola, and Tannerella forsythia. RANKL is a type II homotrimeric transmembrane protein that is expressedas a secretory protein and surrounds the membrane, derived from proteolytic cleavage. RANKL canfunction as an important ligand for the process of osteoclastogenesis. Objective: to determine the effectiveness of Moringa oleifera leaves in influencing RANKL expression in inflammatory pathways. Research Methods: The type of research that will be used is a quasi-experimental witha post-test research design with a control group design. This research was conducted in March - November 2022. Results: On day 0, the average RANKL in the control and treatment groups usingan independent sample t-test showed no significant difference, while on days 7, 14 and 21 the average RANKL in the The control and treatment groups' RANKL scores decreased and the test results showed a significant difference with a p<0.05.