Phosphine-Catalyzed C-Methoxylation of para-Quinone Methides with Methanol and Deuterated Methanol as C1 Sources

被引：3

作者：

Zhong, Yuan ^{[1
]}

Zhang, Dan ^{[1
]}

Li, Guichen ^{[1
]}

Jia, Zhilong ^{[3
]}

Hao, Long ^{[3
]}

Wang, Xin ^{[2
]}

机构：

[1] Gansu Agr Univ, Coll Life Sci & Technol, State Key Lab Aridland Crop Sci, Lanzhou 730070, Peoples R China

[2] Lanzhou Univ, Sch Pharm, Lanzhou 730000, Peoples R China

[3] Gansu Agr Univ, Coll Sci, Lanzhou 730070, Peoples R China

来源：

CHEMISTRYSELECT | 2023年 / 8卷 / 46期

关键词：

phosphine catalysis; C-methoxylation; methanol; p-QMs; deuteration; N-FORMYLATION; 1,6-ADDITION REACTIONS; AMINES; METHYLATION; EFFICIENT; MILD; ALKOXYCARBONYLATION; NITRILES; ALCOHOLS;

D O I：

10.1002/slct.202304341

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

In this work, we developed a phosphine-catalyzed C-methoxylation process of para-quinone methides (p-QMs). By employing a metal-free phosphine catalyst [P(4-MeC6H4)(3)] together with methanol and deuterated methanol (d(4), d(1), and d(3)) as C-1 sources, a series of methoxylated diarylmethanes and the corresponding deuterated products were obtained without additional solvent under mild reaction conditions.

引用

页数：5

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