Tris(pentafluorophenyl)borane-Catalyzed Stereospecific Bromocyanation of Styrene Derivatives with Cyanogen Bromide

被引：2
|
作者：
Kiyokawa, Kensuke [1 ]
Noguchi, Ikumi [1 ]
Nagata, Takaya [1 ]
Minakata, Satoshi [1 ]
机构：
[1] Osaka Univ, Dept Appl Chem, Grad Sch Engn, Suita, Osaka 5650871, Japan
来源：
ORGANIC LETTERS | 2023年 / 25卷 / 14期
关键词：
NICKEL-CATALYZED CARBOCYANATION; INTRAMOLECULAR AMINOCYANATION; ELECTROPHILIC CYANATION; C-C; ALKENES; CYANIDE; PALLADIUM; ACTIVATION; INTERCONVERSION; HYDROCYANATION;
D O I：
10.1021/acs.orglett.3c00727
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
We, herein, report on the bromocyanation of styrene derivatives with cyanogen bromide in the presence of tris(pentafluorophenyl)borane which functions as a Lewis acid catalyst that can effectively activate cyanogen bromide. This reaction proceeds through a stereospecific syn-addition. The protocol is operationally simple and provides practical access to beta-bromonitriles.
引用
收藏
页码：2537 / 2542
页数：6
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