Associations between blood leukocyte DNA methylation and sustained attention in mid-to-late childhood

被引：1
|
作者：
Ehlinger, Jessa, V [1 ]
Goodrich, Jaclyn M. [1 ]
Dolinoy, Dana C. [1 ,2 ]
Watkins, Deborah J. [1 ]
Cantoral, Alejandra [3 ]
Mercado-Garcia, Adriana [4 ]
Tellez-Rojo, Martha M. [4 ]
Peterson, Karen E. [1 ,2 ]
机构：
[1] Univ Michigan, Environm Hlth Sci, Ann Arbor, MI 48109 USA
[2] Univ Michigan, Nutr Sci, Ann Arbor, MI 48109 USA
[3] Iberoamerican Univ, Mexico City 01376, Mexico
[4] Natl Inst Publ Hlth, Cuernavaca 62100, Mexico
来源：
EPIGENOMICS | 2023年
关键词：
adolescent health; child health; DNA methylation; epigenetic epidemiology; epigenetics; neurobehavior; neurodevelopment; DEFICIT/HYPERACTIVITY DISORDER; BIPOLAR DISORDER; ADHD; CHILDREN; TRANSCRIPTION; PERFORMANCE; FERROPTOSIS; DEFICIENCY; MICROARRAY; ZNF804A;
D O I：
10.2217/epi-2023-0169
中图分类号：
Q3 [遗传学];
学科分类号：
071007 ; 090102 ;
摘要：
Aims: To identify associations between DNA methylation (DNAm) across the epigenome and symptoms related to attention-deficit/hyperactivity disorder in a population of Hispanic children. Materials & methods: Among 517 participants in the ELEMENT study aged 9-18 years, we conducted an epigenome-wide association study examining associations between blood leukocyte DNAm and performance on the Conners' continuous performance test (CPT3). Results: DNAm at loci in or near ZNF814, ELF4 and OR6K6 and functional enrichment for gene pathways pertaining to ferroptosis, inflammation, immune response and neurotransmission were significantly related to CPT3 scores. Conclusion: DNAm was associated with CPT3 performance. Further analysis is warranted to understand how these genes and enriched pathways contribute to attention-deficit/hyperactivity disorder.
引用
收藏
页码：965 / 981
页数：17
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