Metal-Phenolic Networks-Reinforced Extracellular Matrix Scaffold for Bone Regeneration via Combining Radical-Scavenging and Photo-Responsive Regulation of Microenvironment

被引：3

作者：

Liu, Zhiqing ^{[1
]}

Wang, Tianlong ^{[1
]}

Zhang, Lei ^{[1
]}

Luo, Yiping ^{[1
]}

Zhao, Jinhui ^{[1
]}

Chen, Yixing ^{[1
]}

Wang, Yao ^{[1
]}

Cao, Wentao ^{[1
]}

Zhao, Xinyu ^{[1
]}

Lu, Bingqiang ^{[1
]}

Chen, Feng ^{[1
]}

Zhou, Zifei ^{[1
]}

Zheng, Longpo ^{[1
,2
,3
]}

机构：

[1] Tongji Univ, Shanghai Peoples Hosp 10, Sch Med, Dept Orthoped, Shanghai 200072, Peoples R China

[2] Shanghai Trauma Emergency Ctr, Shanghai 200072, Peoples R China

[3] Tongji Univ, Peoples Hosp 10, Sch Med, Orthoped Intelligent Minimally Invas Diag & Treatm, Shanghai 200072, Peoples R China

来源：

ADVANCED HEALTHCARE MATERIALS | 2024年 / 13卷 / 15期

基金：

中国国家自然科学基金;

关键词：

bone regeneration; extracellular matrix; metal-phenolic networks; photothermal therapy; radical scavenging; OSTEOCLASTOGENESIS; ANGIOGENESIS; CAPSULES; IONS;

D O I：

10.1002/adhm.202304158

中图分类号：

R318 [生物医学工程];

学科分类号：

0831 ;

摘要：

The limited regulation strategies of the regeneration microenvironment significantly hinder bone defect repair effectiveness. One potential solution is using biomaterials capable of releasing bioactive ions and biomolecules. However, most existing biomaterials lack real-time control features, failing to meet high regulation requirements. Herein, a new Strontium (Sr) and epigallocatechin-3-gallate (EGCG) based metal-phenolic network with polydopamine (PMPNs) modification is prepared. This material reinforces a biomimetic scaffold made of extracellular matrix (ECM) and hydroxyapatite nanowires (nHAW). The PMPNs@ECM/nHAW scaffold demonstrates exceptional scavenging of free radicals and reactive oxygen species (ROS), promoting HUVECs cell migration and angiogenesis, inducing stem cell osteogenic differentiation, and displaying high biocompatibility. Additionally, the PMPNs exhibit excellent photothermal properties, further enhancing the scaffold's bioactivities. In vivo studies confirm that PMPNs@ECM/nHAW with near-infrared (NIR) stimulation significantly promotes angiogenesis and osteogenesis, effectively regulating the microenvironment and facilitating bone tissue repair. This research not only provides a biomimetic scaffold for bone regeneration but also introduces a novel strategy for designing advanced biomaterials. The combination of real-time photothermal intervention and long-term chemical intervention, achieved through the release of bioactive molecules/ions, represents a promising direction for future biomaterial development. Metal-phenolic network with polydopamine (PMPNs) modification endows the biomimetic scaffold made of extracellular matrix (ECM) and hydroxyapatite nanowires (nHAW) with the ability to scavenge free radical, reactive oxygen species (ROS), and photothermal properties. Furthermore, the enhanced release of Sr ions from PMPNs@ECM/nHAW scaffolds due to the responsiveness of PMPNs to ROS provides the biomimetic scaffold with much enhanced angiogenic and osteogenic properties. image

引用

页数：20