Enantioconvergent Reductive C(sp)-C(sp3) Cross-Coupling to Access Chiral α-Alkynyl Phosphonates Under Dual Nickel/Photoredox Catalysis

被引：19
|
作者：
Wang, Hepan [1 ]
Wu, Xiaoqiang [1 ]
Xu, Tao [1 ]
机构：
[1] Tongji Univ, Sch Chem Sci & Engn, Shanghai Key Lab Chem Assessment & Sustainabil, 1239 Siping Rd, Shanghai 200092, Peoples R China
来源：
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION | 2023年 / 62卷 / 18期
关键词：
Alkynes; Cross-Coupling; Metallaphotoredox; Nickel; Phosphorus; ASYMMETRIC ADDITION; PHOTOREDOX; NICKEL; ARYLATION; DIARYLPHOSPHINES; DERIVATIVES; PHOSPHATES; ESTERS;
D O I：
10.1002/anie.202218299
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
Transition-metal-catalyzed asymmetric carbon-carbon bond formation to forge phosphonates with an alpha-chiral carbon center through C(sp(3))-C(sp(3)) and C(sp(2))-C(sp(3)) couplings has been successful. However, the enantioselective C(sp)-C(sp(3)) coupling has not yet been disclosed. Reported herein is an unprecedented enantioconvergent cross-coupling of alkynyl bromides and alpha-bromo phosphonates to deliver chiral alpha-alkynyl phosphonates.
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页数：5
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