Threshold Dynamics of a Degenerate Diffusive HBV Infection Model with DNA-Containing Capsids in Heterogeneous Environment

This paper is concerned with threshold dynamics of a degenerate diffusive HBV infection model with DNA-containing capsids in heterogeneous environment. We firstly address the existence of global solutions, uniform and ultimate boundedness of solutions, asymptotic smoothness of semiflows and existence of a connected global attractor for the diffusive model. Then, we identify the basic reproduction numberR0and establish a threshold-type result for the disease eradication or uniform persistencewhenR(0)<= 1 or R-0>1, respectively. Especially, when R-0>1 and the diffusion rate of capsids or the diffusion rate of virions is zero, we further show that the model admits a unique infection steady state which is globally attractive. Our results indicate that the pathogen can be eliminated by limiting the mobility of the capsids or virions.