One Carbon to Rule Them All: Formaldehyde is a One-Carbon Signal Connecting One-Carbon Metabolism and Epigenetic Methylation

被引：0

作者：

Tenney, Logan ^{[1
]}

Pham, Vanha N. ^{[1
]}

Chang, Christopher J. ^{[2
,3
]}

机构：

[1] Univ Calif Berkeley, Dept Chem, Berkeley, CA 94720 USA

[2] Univ Calif Berkeley, Dept Chem, Dept Mol & Cell Biol, Berkeley, CA 94720 USA

[3] Univ Calif Berkeley, Helen Wills Neurosci Inst, Berkeley, CA 94720 USA

来源：

ACS CHEMICAL BIOLOGY | 2024年 / 19卷 / 04期

基金：

美国国家卫生研究院; 美国国家科学基金会;

关键词：

D O I：

10.1021/acschembio.4c00106

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Formaldehyde is commonly thought of as an environmental toxin or laboratory fixation reagent, but there is a growing appreciation for its broader physiological contributions as a naturally generated one-carbon metabolite across all kingdoms of life. In this In Focus article, we summarize emerging advances in the field that show how formaldehyde plays diverse roles as a one-carbon signal in DNA damage, one-carbon metabolism, and epigenetic regulation.

引用

页码：798 / 801

页数：4

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