The role of biologics in pediatric food allergy and eosinophilic gastrointestinal disorders

被引：15

作者：

Sindher, Sayantani B. ^{[1
]}

Barshow, Suzanne ^{[1
]}

Tirumalasetty, Jyothi ^{[1
]}

Arasi, Stefania ^{[2
]}

Atkins, Dan ^{[3
]}

Bauer, Maureen ^{[3
]}

Begin, Philippe ^{[4
,5
]}

Collins, Margaret H. ^{[6
]}

Deschildre, Antoine ^{[8
]}

Doyle, Alfred D. ^{[9
]}

Fiocchi, Alessandro ^{[2
]}

Furuta, Glenn T. ^{[3
]}

Garcia-Lloret, Maria ^{[10
]}

Mennini, Maurizio ^{[2
]}

Rothenberg, Marc E. ^{[7
]}

Spergel, Jonathan M. ^{[11
]}

Wang, Julie ^{[12
,13
]}

Wood, Robert A. ^{[14
]}

Wright, Benjamin L. ^{[9
]}

Zuberbier, Torsten ^{[15
,16
,17
,18
]}

Chin, Andrew R. ^{[1
]}

Long, Andrew ^{[1
]}

Nadeau, Kari C. ^{[1
]}

Chinthrajah, R. Sharon ^{[1
]}

机构：

[1] Stanford Univ, Sean N Parker Ctr Allergy & Asthma Res, Mountain View, CA USA

[2] Bambino Gesu Pediat Hosp, IRCCS, Div Allergy, Translat Res Paediat Special Area, Rome, Italy

[3] Univ Colorado, Childrens Hosp Colorado, Sch Med, Dept Pediat,Digest Hlth Inst, Colo, Aurora, Philippines

[4] Ctr Hosp Univ St Justine, Dept Pediat Serv Allergy & Clin Immunol, Montreal, PQ, Canada

[5] Ctr Hosp Univ Montreal, Dept Med, Serv Allergy & Clin Immunol, Montreal, PQ, Canada

[6] Univ Cincinnati, Cincinnati Childrens Hosp Med Ctr, Dept Pediat, Div Pathol,Coll Med, Cincinnati, OH USA

[7] Univ Lille, Hop Jeanne Flandre, Pediat Pulmonol & Allergy Dept, CHU Lille, Lille, France

[8] Mayo Clin Arizona, Dept Med, Div Allergy Asthma & Clin Immunol, Scottsdale, AZ USA

[9] UCLA, David Geffen Sch Med, Div Immunol Allergy & Rheumatol, Dept Pediat, Los Angeles, CA USA

[10] Univ Cincinnati, Cincinnati Childrens Hosp Med Ctr, Dept Pediat, Div Allergy & Immunol,Coll Med, Cincinnati, OH USA

[11] Univ Penn, Childrens Hosp Philadelphia, Perelman Sch Med, Div Allergy & Immunol,Dept Pediat, Philadelphia, PA USA

[12] Icahn Sch Med Mt Sinai, Dept Pediat, Div Pediat Allergy & Immunol, New York, NY USA

[13] Jaffe Food Allergy Inst, New York, NY USA

[14] Johns Hopkins Univ, Sch Med, Dept Pediat, Baltimore, MD USA

[15] Charite Univ Med Berlin, Dept Dermatol & Allergy, Dermatol Allergol, Allergie Ctr Charite, Berlin, Germany

[16] Univ Berlin, Berlin, Germany

[17] Humboldt Univ, Berlin, Germany

[18] Berlin Inst Hlth, Berlin, Germany

来源：

JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY | 2023年 / 151卷 / 03期

基金：

美国国家卫生研究院;

关键词：

Food allergy; eosinophilic gastrointestinal disorders; bi-ologics; oral immunotherapy; eosinophilic esophagitis; eosinophilic gastritis; eosinophilic enteritis; eosinophilic colitis; MEDIATED IMMEDIATE HYPERSENSITIVITY; RAPID ORAL DESENSITIZATION; PEANUT ALLERGY; DOUBLE-BLIND; ADRENAL INSUFFICIENCY; COWS MILK; ESOPHAGITIS; IMMUNOTHERAPY; OMALIZUMAB; CHILDREN;

D O I：

10.1016/j.jaci.2023.01.007

中图分类号：

R392 [医学免疫学];

学科分类号：

100102 ;

摘要：

Continuing insight into the molecular mechanisms of atopic disorders has enabled the development of biologics to precisely target these diseases. Food allergy (FA) and eosinophilic gastrointestinal disorders (EGIDs) are driven by similar inflammatory molecular mechanisms and exist along the same atopic disease spectrum. Therefore, many of the same biologics are being investigated to target key drivers of mechanisms shared across the disease states. The enormous potential of biologics for the treatment of FA and EGIDs is highlighted by the significant increases in the number of ongoing clinical trials (more than 30) evaluating their use in these disease states, as well as by the recent US Food and Drug Administration approval of dupilumab for the treatment of eosinophilic esophagitis. Here we discuss past and current research into the use of biologics in FA and EGIDs and their potential role in improving treatment options in the future, with the need to have biologics widely clinically available. (J Allergy Clin Immunol 2023

引用

页码：595 / 606

页数：12

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