Effect of grape-based syrup on cancer-related fatigue in patients with breast cancer: a double-blind randomized clinical trial

Background and Objectives: Cancer-related fatigue (CRF) is a common side effect of cancer that significantly affects patients' quality of life. This study aimed to assess the impact of DEBS syrup, a herbal formulation derived from grape juice, on CRF. Methods: In a double-blind, randomized controlled clinical trial, 70 women with breast cancer and CRF were assigned to either the DEBS or placebo groups. Participants received 10 cc of DEBS syrup or placebo three times daily for four weeks. CRF was measured using the visual analogue scale (VAS), fatigue severity scale (FSS), and cancer fatigue scale (CFS) before and after the intervention. Results: Results showed that DEBS group had significantly higher reductions in FSS, CFS, and VAS scores compared to the placebo group (p = 0.001). Subscale analysis demonstrated significant reductions in somatic, cognitive, and affective domains in the DEBS group. However, only the FSS scores decreased significantly in the placebo group.ConclusionsIn conclusion, DEBS syrup was more effective than placebo in improving CRF among breast cancer patients. Further studies are needed to confirm these findings.Trial registration: Iranian Registry of Clinical Trials identifier: IRCT20190708044149N1. Conclusions: In conclusion, DEBS syrup was more effective than placebo in improving CRF among breast cancer patients. Further studies are needed to confirm these findings.Trial registration: Iranian Registry of Clinical Trials identifier: IRCT20190708044149N1.