SARS-CoV-2 neutralizing antibody titers in maternal blood, umbilical cord blood, and breast milk

被引：1

作者：

Khalifeh, Mazen ^{[1
]}

Rubin, Lorry G. ^{[2
,3
]}

Dayya, David ^{[4
]}

Cerise, Jane ^{[5
]}

Skinner, Karen ^{[1
]}

Maloney, Mona ^{[1
]}

Walworth, Charles ^{[6
]}

Petropoulos, Christos J. ^{[6
]}

Wrin, Terri ^{[6
]}

Chun, Kelly ^{[7
]}

Weinberger, Barry ^{[3
,8
]}

机构：

[1] Phelps Hosp, Div Neonatol & Newborn Med, Northwell Hlth, Sleepy Hollow, NY USA

[2] Northwell Hlth, Cohen Childrens Med Ctr, Div Pediat Infect Dis, New Hyde Pk, NY USA

[3] Zucker Sch Med Hofstra Northwell, New Hyde Pk, NY 11549 USA

[4] Phelps Hosp, Northwell Hlth, Dept Surg, Div Undersea & Hyperbar Med, Sleepy Hollow, NY USA

[5] Northwell Hlth, Biostat Unit, Off Acad Affairs, New Hyde Pk, NY USA

[6] Labcorp Monogram Biosci, South San Francisco, CA 94080 USA

[7] LabCorp Esoterix, Calabasas, CA 91301 USA

[8] Northwell Hlth, Cohen Childrens Med Ctr, Div Neonatal Perinatal Med, New Hyde Pk, NY 11040 USA

来源：

JOURNAL OF PERINATOLOGY | 2024年 / 44卷 / 01期

关键词：

PREGNANCY;

D O I：

10.1038/s41372-023-01843-w

中图分类号：

R71 [妇产科学];

学科分类号：

100211 ;

摘要：

ObjectiveWe quantified neutralizing SARS-CoV-2 antibody against spike protein (nAb) levels after vaccination and SARS-CoV-2 infection in maternal serum, cord blood, and breast milk and determined whether they correlate with levels of spike protein binding antibody.Study designWomen (n = 100) were enrolled on admission for delivery. Previous SARS-CoV-2 infection was defined by anti-nucleocapsid antibodies. Levels of nAb and binding antibodies against spike receptor binding domain were measured in maternal blood, cord blood, and milk.ResultsMaternal nAb levels were higher after vaccine and infection than vaccine alone but waned rapidly. Levels of nAb in cord blood and milk correlated with maternal levels and were higher in cord blood than maternal. Spike protein binding antibody levels correlated with nAb.ConclusionSARS-CoV-2 vaccination near delivery may boost antibody-mediated immunity in the peripartum period. Neutralizing antibodies are passed transplacentally and into milk. Spike protein binding antibody may be a feasible proxy for nAb.

引用

页码：28 / 34

页数：7

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