EXPOSURE-RESPONSE MODELING STRATEGIES IN ONCOLOGY: IMPACT OF DOSE REDUCTIONS ON INTERPRETATION OF RESULTS.

被引:0
|
作者
Yue, M. [1 ,2 ]
Lombard, A. [3 ]
Pitou, C. [4 ]
Chigutsa, E. [2 ]
机构
[1] Purdue Univ, W Lafayette, IN 47907 USA
[2] Eli Lilly & Co, Indianapolis, IN 46285 USA
[3] Eli Lilly & Co, Neuilly Sur Seine, France
[4] Eli Lilly & Co, London, England
关键词
D O I
暂无
中图分类号
R9 [药学];
学科分类号
1007 ;
摘要
PI-069
引用
收藏
页码:S35 / S35
页数:1
相关论文
共 50 条
  • [1] Dose/exposure-response modeling in dose titration trials: Overcoming the titration paradox
    Kristensen, Niels Rode
    Agerso, Henrik
    [J]. CPT-PHARMACOMETRICS & SYSTEMS PHARMACOLOGY, 2022, 11 (12): : 1592 - 1603
  • [2] Confounding factors in exposure-response analyses and mitigation strategies for monoclonal antibodies in oncology
    Kawakatsu, Sonoko
    Bruno, Rene
    Kagedal, Matts
    Li, Chunze
    Girish, Sandhya
    Joshi, Amita
    Wu, Benjamin
    [J]. BRITISH JOURNAL OF CLINICAL PHARMACOLOGY, 2021, 87 (06) : 2493 - 2501
  • [3] Pharmacometrics Golems: Exposure-Response Models in Oncology
    Khandelwal, Akash
    Grisic, Ana-Marija
    French, Jonathan
    Venkatakrishnan, Karthik
    [J]. CLINICAL PHARMACOLOGY & THERAPEUTICS, 2022, 112 (05) : 941 - 945
  • [4] Impact of Dose Reduction on Efficacy: Implications of Exposure-Response Analysis of Palbociclib
    Jenny Zheng
    Yanke Yu
    Chandrasekar Durairaj
    Véronique Diéras
    Richard S. Finn
    Diane D. Wang
    [J]. Targeted Oncology, 2021, 16 : 69 - 76
  • [5] Impact of Dose Reduction on Efficacy: Implications of Exposure-Response Analysis of Palbociclib
    Zheng, Jenny
    Yu, Yanke
    Durairaj, Chandrasekar
    Dieras, Veronique
    Finn, Richard S.
    Wang, Diane D.
    [J]. TARGETED ONCOLOGY, 2021, 16 (01) : 69 - 76
  • [6] An Exposure-Response Perspective on the Clinical Dose of Pretomanid
    Nedelman, Jerry R.
    Salinger, David H.
    Subramoney, Vishak
    Woolson, Rob
    Wade, Karen
    Li, Mengchun
    Everitt, Daniel
    Mendel, Carl M.
    Spigelman, Mel
    [J]. ANTIMICROBIAL AGENTS AND CHEMOTHERAPY, 2021, 65 (01)
  • [7] EVALUATION OF OZONE EXPOSURE INDEXES IN EXPOSURE-RESPONSE MODELING
    LEE, EH
    TINGEY, DT
    HOGSETT, WE
    [J]. ENVIRONMENTAL POLLUTION, 1988, 53 (1-4) : 43 - 62
  • [8] Abatacept Exposure-Response Analysis and its Impact on Dose Selection in Lupus Nephritis
    Suryawanshi, Satyendra
    Tagen, Michael
    Murthy, Bindu
    Hillson, Jan
    Roy, Amit
    [J]. JOURNAL OF PHARMACOKINETICS AND PHARMACODYNAMICS, 2013, 40 : S48 - S48
  • [9] Dose- and Exposure-Response to Ketamine in Depression
    Glue, Paul
    Gulati, Abhishek
    Le Nedelec, Martin
    Duffull, Stephen
    [J]. BIOLOGICAL PSYCHIATRY, 2011, 70 (04) : E9 - E10
  • [10] ABATACEPT EXPOSURE-RESPONSE ANALYSIS AND ITS IMPACT ON DOSE SELECTION IN LUPUS NEPHRITIS
    Suryawanshi, S.
    Tagen, M.
    Murthy, B.
    Hillson, J.
    Roy, A.
    [J]. ANNALS OF THE RHEUMATIC DISEASES, 2013, 72 : 480 - 480