Non-small cell lung cancer patient with a rare UGP2-ALK fusion protein responded well to alectinib: a case report
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Chen, Liulin
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AF Mil Med Univ, Tangdu Hosp, Dept Resp & Crit Care Med, 569 Xinsi Rd, Xian 710038, Shaanxi, Peoples R ChinaAF Mil Med Univ, Tangdu Hosp, Dept Resp & Crit Care Med, 569 Xinsi Rd, Xian 710038, Shaanxi, Peoples R China
Chen, Liulin
[1
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Chu, Daifang
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AF Mil Med Univ, Tangdu Hosp, Dept Resp & Crit Care Med, 569 Xinsi Rd, Xian 710038, Shaanxi, Peoples R ChinaAF Mil Med Univ, Tangdu Hosp, Dept Resp & Crit Care Med, 569 Xinsi Rd, Xian 710038, Shaanxi, Peoples R China
Chu, Daifang
[1
]
Li, Wangping
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AF Mil Med Univ, Tangdu Hosp, Dept Resp & Crit Care Med, 569 Xinsi Rd, Xian 710038, Shaanxi, Peoples R ChinaAF Mil Med Univ, Tangdu Hosp, Dept Resp & Crit Care Med, 569 Xinsi Rd, Xian 710038, Shaanxi, Peoples R China
Li, Wangping
[1
]
Zhang, Haitao
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AF Mil Med Univ, Tangdu Hosp, Dept Resp & Crit Care Med, 569 Xinsi Rd, Xian 710038, Shaanxi, Peoples R ChinaAF Mil Med Univ, Tangdu Hosp, Dept Resp & Crit Care Med, 569 Xinsi Rd, Xian 710038, Shaanxi, Peoples R China
Zhang, Haitao
[1
]
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[1] AF Mil Med Univ, Tangdu Hosp, Dept Resp & Crit Care Med, 569 Xinsi Rd, Xian 710038, Shaanxi, Peoples R China
Several rare anaplastic lymphoma kinase (ALK) fusions have been identified in patients with non-small cell lung cancer (NSCLC); however, their treatment is not currently uniform. alectinib has been commonly used to treat rare ALK fusions in patients with NSCLC. This is the first study to report the occurrence of a uridine diphosphate-glucose pyrophosphorylase 2 (UGP2)-ALK fusion in a patient with NSCLC. The patient, who was hospitalized because of shortness of breath lasting 20 days, showed hydrothorax of the left lung under a computerized tomography chest scan. Pathological histology revealed lung adenocarcinoma in the patient. The UGP2-ALK mutation was found by next-generation sequencing. Subsequently, the patient was administered alectinib, and thereafter, the tumor lesion was observed to gradually shrink over the follow-up period. Progression-free survival reached 10 months as of the follow-up date, with no adverse events detected. This case report provides valuable insights into the clinical management of NSCLC patients with UGP2-ALK fusions. Moreover, alectinib is confirmed to be an appropriate therapeutic agent for such patients.
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Montpellier Univ, Inst Canc Montpellier ICM, Med Oncol Dept, Montpellier, FranceMontpellier Univ, Inst Canc Montpellier ICM, Med Oncol Dept, Montpellier, France
Thomas, Quentin Dominique
Pautas, Marie
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Inst Curie, Med Oncol Dept, Paris, France
Paris Saclay Univ, St Aubin, FranceMontpellier Univ, Inst Canc Montpellier ICM, Med Oncol Dept, Montpellier, France
Pautas, Marie
Guilhaume, Marie-Noelle
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Inst Curie, Med Oncol Dept, Paris, France
Paris Saclay Univ, St Aubin, FranceMontpellier Univ, Inst Canc Montpellier ICM, Med Oncol Dept, Montpellier, France
Guilhaume, Marie-Noelle
Fiteni, Frederic
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CHU Nimes, Med Oncol Dept, Nimes, FranceMontpellier Univ, Inst Canc Montpellier ICM, Med Oncol Dept, Montpellier, France
Fiteni, Frederic
Ge, Tony
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Inst Curie, Med Oncol Dept, Paris, France
Paris Saclay Univ, St Aubin, FranceMontpellier Univ, Inst Canc Montpellier ICM, Med Oncol Dept, Montpellier, France
Ge, Tony
Girard, Nicolas
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Inst Curie, Med Oncol Dept, Paris, France
Paris Saclay Univ, St Aubin, FranceMontpellier Univ, Inst Canc Montpellier ICM, Med Oncol Dept, Montpellier, France
机构:
Peking Univ First Hosp, Dept Resp & Crit Care Med, 8 Xishiku St, Beijing 100034, Peoples R ChinaPeking Univ First Hosp, Dept Resp & Crit Care Med, 8 Xishiku St, Beijing 100034, Peoples R China
Sun, Kunyan
Nie, Ligong
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Peking Univ First Hosp, Dept Resp & Crit Care Med, 8 Xishiku St, Beijing 100034, Peoples R ChinaPeking Univ First Hosp, Dept Resp & Crit Care Med, 8 Xishiku St, Beijing 100034, Peoples R China
Nie, Ligong
Nong, Lin
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Peking Univ First Hosp, Dept Pathol, Beijing, Peoples R ChinaPeking Univ First Hosp, Dept Resp & Crit Care Med, 8 Xishiku St, Beijing 100034, Peoples R China
Nong, Lin
Cheng, Yuan
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Peking Univ First Hosp, Dept Resp & Crit Care Med, 8 Xishiku St, Beijing 100034, Peoples R ChinaPeking Univ First Hosp, Dept Resp & Crit Care Med, 8 Xishiku St, Beijing 100034, Peoples R China
机构:
Nippon Med Sch, Grad Sch Med, Dept Pulm Med & Oncol, Tokyo 1138603, JapanNippon Med Sch, Grad Sch Med, Dept Pulm Med & Oncol, Tokyo 1138603, Japan
Misawa, Kazuhito
Nakamichi, Shinji
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Nippon Med Sch, Grad Sch Med, Dept Pulm Med & Oncol, Tokyo 1138603, Japan
Nippon Med Sch, Grad Sch Med, Dept Pulm Med & Oncol, 1-1-5, Sendagi,Bunkyo Ku, Tokyo 1138603, JapanNippon Med Sch, Grad Sch Med, Dept Pulm Med & Oncol, Tokyo 1138603, Japan
Nakamichi, Shinji
Iida, Hiroki
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Nippon Med Sch, Grad Sch Med, Dept Pulm Med & Oncol, Tokyo 1138603, JapanNippon Med Sch, Grad Sch Med, Dept Pulm Med & Oncol, Tokyo 1138603, Japan
Iida, Hiroki
Nagano, Atsuhiro
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Nippon Med Sch, Grad Sch Med, Dept Pulm Med & Oncol, Tokyo 1138603, JapanNippon Med Sch, Grad Sch Med, Dept Pulm Med & Oncol, Tokyo 1138603, Japan
Nagano, Atsuhiro
Mikami, Erika
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Nippon Med Sch, Grad Sch Med, Dept Pulm Med & Oncol, Tokyo 1138603, JapanNippon Med Sch, Grad Sch Med, Dept Pulm Med & Oncol, Tokyo 1138603, Japan
Mikami, Erika
Tozuka, Takehiro
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Nippon Med Sch, Grad Sch Med, Dept Pulm Med & Oncol, Tokyo 1138603, JapanNippon Med Sch, Grad Sch Med, Dept Pulm Med & Oncol, Tokyo 1138603, Japan
Tozuka, Takehiro
Matsumoto, Masaru
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Nippon Med Sch, Grad Sch Med, Dept Pulm Med & Oncol, Tokyo 1138603, JapanNippon Med Sch, Grad Sch Med, Dept Pulm Med & Oncol, Tokyo 1138603, Japan
Matsumoto, Masaru
Miyanaga, Akihiko
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Nippon Med Sch, Grad Sch Med, Dept Pulm Med & Oncol, Tokyo 1138603, JapanNippon Med Sch, Grad Sch Med, Dept Pulm Med & Oncol, Tokyo 1138603, Japan
Miyanaga, Akihiko
Noro, Rintaro
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Nippon Med Sch, Grad Sch Med, Dept Pulm Med & Oncol, Tokyo 1138603, JapanNippon Med Sch, Grad Sch Med, Dept Pulm Med & Oncol, Tokyo 1138603, Japan
Noro, Rintaro
Kubota, Kaoru
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Nippon Med Sch, Grad Sch Med, Dept Pulm Med & Oncol, Tokyo 1138603, JapanNippon Med Sch, Grad Sch Med, Dept Pulm Med & Oncol, Tokyo 1138603, Japan
Kubota, Kaoru
Yamaguchi, Hiroki
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Nippon Med Sch, Dept Hematol, Tokyo 1138603, JapanNippon Med Sch, Grad Sch Med, Dept Pulm Med & Oncol, Tokyo 1138603, Japan
Yamaguchi, Hiroki
Seike, Masahiro
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Nippon Med Sch, Grad Sch Med, Dept Pulm Med & Oncol, Tokyo 1138603, JapanNippon Med Sch, Grad Sch Med, Dept Pulm Med & Oncol, Tokyo 1138603, Japan