Racial disparities in cascade testing for cancer predisposition genes

被引:4
|
作者
Kassem, Nawal M. [3 ]
Althouse, Sandra K.
Monahan, Patrick O.
Hayes, Lisa
Nielsen, Sarah M. [1 ,2 ]
Heald, Brandie [1 ,2 ]
Esplin, Edward D. [1 ,2 ]
Hatchell, Kathryn E. [1 ,2 ]
Ballinger, Tarah J.
机构
[1] Indiana Univ Sch Med, Dept Med, Indianapolis, IN 46202 USA
[2] Invitae, 1400 16th St, San Francisco, CA 94103 USA
[3] Indiana Univ Sch Med, 535 Barnhill Dr RT 411, Indianapolis, IN 46202 USA
关键词
Genetic testing; Cascade testing; Disparity; cancer prevention; Hereditary cancer syndrome; COMMUNICATION; POPULATION; RELATIVES; BREAST; WOMEN; RISK;
D O I
10.1016/j.ypmed.2023.107539
中图分类号
R1 [预防医学、卫生学];
学科分类号
1004 ; 120402 ;
摘要
We sought to determine whether there are racial disparities in cascade testing rates and whether providing testing at no-charge impacts rates in Black and White at-risk-relatives (ARR). Probands with a pathogenic/likely pathogenic germline variant in a cancer predisposition gene were identified up to one year before and up to one year after cascade testing became no-charge in 2017. Cascade testing rates were measured as the proportion of probands who had at least one ARR obtain genetic testing through one commercial laboratory. Rates were compared between self-reported Black and White probands using logistic regression. Interaction between race and cost (pre/post policy) was tested. Significantly fewer Black probands than White probands had at least one ARR undergo cascade genetic testing (11.9% versus 21.7%, OR 0.49, 95% CI 0.39-0.61, p < 0.0001). This was seen both before (OR 0.38, 95% CI 0.24-0.61, p < 0.001) and after (OR 0.53, 95% CI 0.41-0.68, p < 0.001) the no-charge testing policy. Rates of an ARR undergoing cascade testing were low overall, and significantly lower in Black versus White probands. The magnitude of difference in cascade testing rates between Blacks and Whites did not significantly change with no-charge testing. Barriers to cascade testing in all populations should be explored in order to maximize the benefits of genetic testing for both treatment and prevention of cancer.
引用
收藏
页数:4
相关论文
共 50 条
  • [1] Racial Disparities in Family Variant Testing for Cancer Predisposition Genes
    Kassem, N.
    Althouse, S. K.
    Monahan, P.
    Hayes, L.
    Nielsen, S. M.
    Heald, B.
    Esplin, E.
    Hatchell, K. E.
    Ballinger, T. J.
    CANCER EPIDEMIOLOGY BIOMARKERS & PREVENTION, 2022, 31 (07) : 1511 - 1511
  • [2] Mainstreaming genetic testing of cancer predisposition genes
    Rahman, Nazneen
    CLINICAL MEDICINE, 2014, 14 (04) : 436 - 439
  • [3] Racial and ethnic differences in the results of multigene panel testing of inherited cancer predisposition genes in breast cancer patients.
    Yadav, Siddhartha
    LaDuca, Holly
    Polley, Eric
    Shimelis, Hermela
    Niguidula, Nancy
    Hu, Chunling
    Lilyquist, Jenna
    Na, Jie
    Lee, Kun
    Gutierrez, Stephanie
    Yussuf, Amal
    Hart, Steven
    Davis, Brigette Tippin
    Chao, Elizabeth
    Pesaran, Tina
    Goldgar, David
    Dolinsky, Jill S.
    Couch, Fergus
    JOURNAL OF CLINICAL ONCOLOGY, 2019, 37 (15)
  • [4] Index case identification and outcomes of cascade testing in high-risk breast and colorectal cancer predisposition genes
    Malak Abedalthagafi
    European Journal of Human Genetics, 2022, 30 : 392 - 393
  • [5] Index case identification and outcomes of cascade testing in high-risk breast and colorectal cancer predisposition genes
    Abedalthagafi, Malak
    EUROPEAN JOURNAL OF HUMAN GENETICS, 2022, 30 (04) : 392 - 393
  • [6] Impact of free cancer predisposition cascade genetic testing on uptake in Singapore
    Courtney, Eliza
    Chok, Amanda Kay-Lyn
    Ang, Zoe Li Ting
    Shaw, Tarryn
    Li, Shao-Tzu
    Yuen, Jeanette
    Ngeow, Joanne
    NPJ GENOMIC MEDICINE, 2019, 4 (1)
  • [7] Impact of free cancer predisposition cascade genetic testing on uptake in Singapore
    Eliza Courtney
    Amanda Kay-Lyn Chok
    Zoe Li Ting Ang
    Tarryn Shaw
    Shao-Tzu Li
    Jeanette Yuen
    Joanne Ngeow
    npj Genomic Medicine, 4
  • [8] Associations Between Cancer Predisposition Testing Panel Genes and Breast Cancer
    Couch, Fergus J.
    Shimelis, Hermela
    Hu, Chunling
    Hart, Steven N.
    Polley, Eric C.
    Na, Jie
    Hallberg, Emily
    Moore, Raymond
    Thomas, Abigail
    Lilyquist, Jenna
    Feng, Bingjian
    McFarland, Rachel
    Pesaran, Tina
    Huether, Robert
    LaDuca, Holly
    Chao, Elizabeth C.
    Goldgar, David E.
    Dolinsky, Jill S.
    JAMA ONCOLOGY, 2017, 3 (09) : 1190 - 1196
  • [9] Disparities in germline testing among racial minorities with prostate cancer
    Nicole Weise
    Justin Shaya
    Juan Javier-Desloges
    Heather H. Cheng
    Lisa Madlensky
    Rana R. McKay
    Prostate Cancer and Prostatic Diseases, 2022, 25 : 403 - 410
  • [10] Racial disparities in genetic testing of breast cancer patients.
    Bayard, Solange
    Chen, Yalei
    Fasano, Genevieve A.
    Davis, Melissa
    Walker, Eleanor M.
    Bensenhaver, Jessica Miley
    Petersen, Lindsay
    Marti, Jennifer
    Simmons, Rache M.
    Swistel, Alexander J.
    Newman, Lisa A.
    JOURNAL OF CLINICAL ONCOLOGY, 2021, 39 (15)