Impact of 18FFDG-PET/CT and Laparoscopy in Staging of Locally Advanced Gastric Cancer: A Cost Analysis in the Prospective Multicenter PLASTIC-Study

被引：2

作者：

de Jongh, Cas ^{[1
]}

van der Meulen, Miriam P. ^{[2
]}

Gertsen, Emma C. ^{[1
]}

Brenkman, Hylke J. F. ^{[1
]}

van Sandick, Johanna W. ^{[3
]}

van Berge Henegouwen, Mark I. ^{[4
,5
]}

Gisbertz, Suzanne S. ^{[4
,5
]}

Luyer, Misha D. P. ^{[6
]}

Nieuwenhuijzen, Grard A. P. ^{[6
]}

van Lanschot, Jan J. B. ^{[7
]}

Lagarde, Sjoerd M. ^{[7
]}

Wijnhoven, Bas P. L. ^{[7
]}

de Steur, Wobbe O. ^{[8
]}

Hartgrink, Henk H. ^{[8
]}

Stoot, Jan H. M. B. ^{[9
]}

Hulsewe, Karel W. E. ^{[9
]}

Spillenaar Bilgen, Ernst Jan ^{[10
]}

van Det, Marc J. ^{[11
]}

Kouwenhoven, Ewout A. ^{[11
]}

Daams, Freek ^{[5
,12
]}

van der Peet, Donald L. ^{[5
,12
]}

van Grieken, Nicole C. T. ^{[5
,12
]}

Heisterkamp, Joos ^{[13
]}

van Etten, Boudewijn ^{[14
]}

van den Berg, Jan-Willem ^{[14
]}

Pierie, Jean-Pierre ^{[15
]}

Eker, Hasan H. ^{[15
]}

Thijssen, Annemieke Y. ^{[16
]}

Belt, Eric J. T. ^{[16
]}

van Duijvendijk, Peter ^{[17
]}

Wassenaar, Eelco ^{[17
]}

Wevers, Kevin P. ^{[18
]}

Hol, Lieke ^{[19
]}

Wessels, Frank J. ^{[1
]}

Haj Mohammad, Nadia ^{[1
]}

Frederix, Geert W. J. ^{[2
]}

van Hillegersberg, Richard ^{[1
]}

Siersema, Peter D. ^{[20
]}

Vegt, Erik ^{[3
,7
]}

Ruurda, Jelle P. ^{[1
]}

机构：

[1] UMC Utrecht, Dept Surg Med Oncol & Radiol, Univ Med Ctr, Utrecht, Netherlands

[2] UMC Utrecht, Julius Ctr Hlth Sci & Primary Care, Utrecht, Netherlands

[3] Netherlands Canc Inst Antoni Leeuwenhoek, Surg & Nucl Med Dept, Amsterdam, Netherlands

[4] Locat Univ Amsterdam, Surg Dept, Amsterdam UMC, Amsterdam, Netherlands

[5] Canc Ctr Amsterdam, Surg & Pathol Dept, Amsterdam, Netherlands

[6] Catharina Hosp, Surg Dept, Eindhoven, Netherlands

[7] UMC Rotterdam, Surg & Nucl Med Dept, Erasmus Med Ctr, Rotterdam, Netherlands

[8] Leiden UMC, Surg Dept, Leiden, Netherlands

[9] Zuyderland MC, Surg Dept, Geleen, Netherlands

[10] Rijnstate Hosp, Surg Dept, Arnhem, Netherlands

[11] ZGT Hosp, Surg Dept, Almelo, Netherlands

[12] Amsterdam UMC, Locat Vrije Univ, Surg & Pathol Dept, Amsterdam, Netherlands

[13] Elisabeth Twee Steden Hosp, Surg Dept, Tilburg, Netherlands

[14] Univ Med Ctr Groningen, Surg Dept, Groningen, Netherlands

[15] Med Ctr Leeuwarden, Surg Dept, Leeuwarden, Netherlands

[16] Albert Schweitzer Hosp, Gastroenterol Dept, Dordrecht, Netherlands

[17] Gelre Hosp, Surg Dept, Apeldoorn, Netherlands

[18] Isala Hosp, Surg Dept, Zwolle, Netherlands

[19] Maasstad Hosp, Gastroenterol Dept, Rotterdam, Netherlands

[20] Erasmus MC Univ Med Ctr, Gastroenterol & Hepatol Dept, Rotterdam, Netherlands

来源：

ANNALS OF SURGICAL ONCOLOGY | 2024年 / 31卷 / 6期

关键词：

Gastric cancer; Costs; Staging; Positron emission tomography; Laparoscopy; Gastrectomy; POSITRON-EMISSION-TOMOGRAPHY; GASTROINTESTINAL CANCER; CHEMOTHERAPY; SURGERY; TUMOR;

D O I：

10.1245/s10434-024-15103-4

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Background Unnecessary D2-gastrectomy and associated costs can be prevented after detecting non-curable gastric cancer, but impact of staging on treatment costs is unclear. This study determined the cost impact of 18F-fluorodeoxyglucose positron emission tomography/computed tomography (18FFDG-PET/CT) and staging laparoscopy (SL) in gastric cancer staging. Materials and Methods In this cost analysis, four staging strategies were modeled in a decision tree: (1) 18FFDG-PET/CT first, then SL, (2) SL only, (3) 18FFDG-PET/CT only, and (4) neither SL nor 18FFDG-PET/CT. Costs were assessed on the basis of the prospective PLASTIC-study, which evaluated adding 18FFDG-PET/CT and SL to staging advanced gastric cancer (cT3-4 and/or cN+) in 18 Dutch hospitals. The Dutch Healthcare Authority provided 18FFDG-PET/CT unit costs. SL unit costs were calculated bottom-up. Gastrectomy-associated costs were collected with hospital claim data until 30 days postoperatively. Uncertainty was assessed in a probabilistic sensitivity analysis (1000 iterations). Results 18FFDG-PET/CT costs were euro1104 including biopsy/cytology. Bottom-up calculations totaled euro1537 per SL. D2-gastrectomy costs were euro19,308. Total costs per patient were euro18,137 for strategy 1, euro17,079 for strategy 2, and euro19,805 for strategy 3. If all patients undergo gastrectomy, total costs were euro18,959 per patient (strategy 4). Performing SL only reduced costs by euro1880 per patient. Adding 18FFDG-PET/CT to SL increased costs by euro1058 per patient; IQR euro870-1253 in the sensitivity analysis. Conclusions For advanced gastric cancer, performing SL resulted in substantial cost savings by reducing unnecessary gastrectomies. In contrast, routine 18FFDG-PET/CT increased costs without substantially reducing unnecessary gastrectomies, and is not recommended due to limited impact with major costs. Trial registration: NCT03208621. This trial was registered prospectively on 30-06-2017. Conclusions For advanced gastric cancer, performing SL resulted in substantial cost savings by reducing unnecessary gastrectomies. In contrast, routine 18FFDG-PET/CT increased costs without substantially reducing unnecessary gastrectomies, and is not recommended due to limited impact with major costs. Trial registration: NCT03208621. This trial was registered prospectively on 30-06-2017.

引用

页码：4005 / 4017

页数：13

共 50 条

[1] Impact of 18FFDG-PET/CT and Laparoscopy in Staging of Locally Advanced Gastric Cancer: A Cost Analysis in the Prospective Multicenter PLASTIC-Study
Cas de Jongh
Miriam P. van der Meulen
Emma C. Gertsen
Hylke J. F. Brenkman
Johanna W. van Sandick
Mark I. van Berge Henegouwen
Suzanne S. Gisbertz
Misha D. P. Luyer
Grard A. P. Nieuwenhuijzen
Jan J. B. van Lanschot
Sjoerd M. Lagarde
Bas P. L. Wijnhoven
Wobbe O. de Steur
Henk H. Hartgrink
Jan H. M. B. Stoot
Karel W. E. Hulsewe
Ernst Jan Spillenaar Bilgen
Marc J. van Det
Ewout A. Kouwenhoven
Freek Daams
Donald L. van der Peet
Nicole C. T. van Grieken
Joos Heisterkamp
Boudewijn van Etten
Jan-Willem van den Berg
Jean-Pierre Pierie
Hasan H. Eker
Annemieke Y. Thijssen
Eric J. T. Belt
Peter van Duijvendijk
Eelco Wassenaar
Kevin P. Wevers
Lieke Hol
Frank J. Wessels
Nadia Haj Mohammad
Geert W. J. Frederix
Richard van Hillegersberg
Peter D. Siersema
Erik Vegt
Jelle P. Ruurda
[J]. Annals of Surgical Oncology, 2024, 31 : 4005 - 4017
[2] Evaluation of PET and laparoscopy in STagIng advanced gastric cancer: a multicenter prospective study (PLASTIC-study)
Brenkman, H. J. F.
Gertsen, E. C.
Vegt, E.
van Hillegersberg, R.
Henegouwen, M. I. van Berge
Gisbertz, S. S.
Luyer, M. D. P.
Nieuwenhuijzen, G. A. P.
van Lanschot, J. J. B.
Lagarde, S. M.
de Steur, W. O.
Hartgrink, H. H.
Stoot, J. H. M. B.
Hulsewe, K. W. E.
Bilgen, E. J. Spillenaar
van Det, M. J.
Kouwenhoven, E. A.
van der Peet, D. L.
Daams, F.
van Sandick, J. W.
van Grieken, N. C. T.
Heisterkamp, J.
van Etten, B.
Haveman, J. W.
Pierie, J. P.
Jonker, F.
Thijssen, A. Y.
Belt, E. J. T.
van Duijvendijk, P.
Wassenaar, E.
van Laarhoven, H. W. M.
Wessels, F. J.
Mohammad, N. Haj
van Stel, H. F.
Frederix, G. W. J.
Siersema, P. D.
Ruurda, J. P.
[J]. BMC CANCER, 2018, 18
[3] Evaluation of PET and laparoscopy in STagIng advanced gastric cancer: a multicenter prospective study (PLASTIC-study)
H. J. F. Brenkman
E. C. Gertsen
E. Vegt
R. van Hillegersberg
M. I. van Berge Henegouwen
S. S. Gisbertz
M. D. P. Luyer
G. A. P. Nieuwenhuijzen
J. J. B. van Lanschot
S. M. Lagarde
W. O. de Steur
H. H. Hartgrink
J. H. M. B. Stoot
K. W. E. Hulsewe
E. J. Spillenaar Bilgen
M. J. van Det
E. A. Kouwenhoven
D. L. van der Peet
F. Daams
J. W. van Sandick
N. C. T. van Grieken
J. Heisterkamp
B. van Etten
J. W. Haveman
J. P. Pierie
F. Jonker
A. Y. Thijssen
E. J. T. Belt
P. van Duijvendijk
E. Wassenaar
H. W. M. van Laarhoven
F. J. Wessels
N. Haj Mohammad
H. F. van Stel
G. W. J. Frederix
P. D. Siersema
J. P. Ruurda
[J]. BMC Cancer, 18
[4] Staging laparoscopy for locally advanced gastric cancer in Chinese patients: a multicenter prospective registry study
Ziyu Li
Zhemin Li
Lianhai Zhang
Qian Liu
Zhenjun Wang
Zhongtao Zhang
Gang Xiao
Wei Fu
Xin Wang
Yingjiang Ye
Jianchun Yu
Fei Li
Lin Chen
Shibin Wang
Jiafu Ji
[J]. BMC Cancer, 18
[5] Staging laparoscopy for locally advanced gastric cancer in Chinese patients: a multicenter prospective registry study
Li, Ziyu
Li, Zhemin
Zhang, Lianhai
Liu, Qian
Wang, Zhenjun
Zhang, Zhongtao
Xiao, Gang
Fu, Wei
Wang, Xin
Ye, Yingjiang
Yu, Jianchun
Li, Fei
Chen, Lin
Wang, Shibin
Ji, Jiafu
[J]. BMC CANCER, 2018, 18
[6] 18F-Fludeoxyglucose-Positron Emission Tomography/Computed Tomography and Laparoscopy for Staging of Locally Advanced Gastric Cancer A Multicenter Prospective Dutch Cohort Study (PLASTIC)
Gertsen, Emma C.
Brenkman, Hylke J. F.
van Hillegersberg, Richard
van Sandick, Johanna W.
Henegouwen, Mark I. van Berge
Gisbertz, Suzanne S.
Luyer, Misha D. P.
Nieuwenhuijzen, Grard A. P.
van Lanschot, Jan J. B.
Lagarde, Sjoerd M.
Wijnhoven, Bas P. L.
de Steur, Wobbe O.
Hartgrink, Henk H.
Stoot, Jan H. M. B.
Hulsewe, Karel W. E.
Bilgen, Ernst J. Spillenaar
van Det, Marc J.
Kouwenhoven, Ewout A.
van der Peet, Donald L.
Daams, Freek
van Grieken, Nicole C. T.
Heisterkamp, Joos
van Etten, Boudewijn
van den Berg, Jan Willem
Pierie, Jean Pierre
Eker, Hasan H.
Thijssen, Annemieke Y.
Belt, Eric J. T.
van Duijvendijk, Peter
Wassenaar, Eelco
van Laarhoven, Hanneke W. M.
Wevers, Kevin P.
Hol, Lieke
Wessels, Frank J.
Mohammad, Nadia Haj
van der Meulen, Miriam P.
Frederix, Geert W. J.
Vegt, Erik
Siersema, Peter D.
Ruurda, Jelle P.
[J]. JAMA SURGERY, 2021, 156 (12) : E1 - E9
[7] Impact of 18-F FDG PET/CT on staging of locally advanced breast cancer
Rashki, M.
Sanchez Sanchez, R.
Gonzalez Jimenez, A.
Rebollo Aguirre, A.
Culianez Casas, M.
Menjon Beltran, S.
LLamas Elvira, J.
[J]. EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING, 2018, 45 : S461 - S461
[8] Impact of 18F-FDG-PET/CT on Staging and Irradiation of Patients with Locally Advanced Rectal Cancer
Paskeviciute, Brigita
Boelling, Tobias
Brinkmann, Markus
Rudykina, Ganna
Ernst, Iris
Stegger, Lars
Schober, Otmar
Willich, Normann
Weckesser, Matthias
Koenemann, Stefan
[J]. STRAHLENTHERAPIE UND ONKOLOGIE, 2009, 185 (04) : 260 - 265
[9] Clinical impact of PET/CT in paraaortic staging in patients with locally advanced cervical cancer
Abadi Sedraoui, Y.
Coronado Poggio, M.
Lancha Hernandez, C.
Cordero Garcia, J.
Escabias Del Pozo, C.
Rodado Marina, S.
Rizkallal Monzon, S.
Travaglio Morales, D.
Lopez Llobet, E.
Giraldo Gonzalez, L.
Dominguez Gadea, L.
[J]. EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING, 2022, 49 (SUPPL 1) : S516 - S516
[10] 18FDG PET staging versus conventional (CT scan and laparoscopy) staging in advanced epithelial ovarian cancer: correlation with survival
Zamagni, C.
Rosati, M.
Musto, A.
Maccarini, L. Ricci
Quercia, S.
Bernardi, A.
Rubino, D.
De Iaco, P.
Fanti, S.
Martoni, A. A.
[J]. EJC SUPPLEMENTS, 2009, 7 (02): : 457 - 457

← 1 2 3 4 5 →