Shear Stress and Endothelial Mechanotransduction in Trauma Patients with Hemorrhagic Shock: Hidden Coagulopathy Pathways and Novel Therapeutic Strategies

被引:10
|
作者
Chalkias, Athanasios [1 ,2 ]
机构
[1] Univ Penn, Inst Translat Med & Therapeut, Perelman Sch Med, Philadelphia, PA 19104 USA
[2] Outcomes Res Consortium, Cleveland, OH 44195 USA
关键词
blood flow; microcirculation; endothelium; endothelial cell; mechanotransduction; mechanosensing; coagulation; translational research; critical care medicine; centhaquine; ISCHEMIA-REPERFUSION INJURY; WEIBEL-PALADE BODIES; PLASMINOGEN-ACTIVATOR; COAGULATION FUNCTION; HEPARAN-SULFATE; FACTOR-VIII; BLOOD-FLOW; SYMPATHOADRENAL ACTIVATION; PLATELET-FUNCTION; OXIDATIVE STRESS;
D O I
10.3390/ijms242417522
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
Massive trauma remains a leading cause of death and a global public health burden. Post-traumatic coagulopathy may be present even before the onset of resuscitation, and correlates with severity of trauma. Several mechanisms have been proposed to explain the development of abnormal coagulation processes, but the heterogeneity in injuries and patient profiles makes it difficult to define a dominant mechanism. Regardless of the pattern of death, a significant role in the pathophysiology and pathogenesis of coagulopathy may be attributed to the exposure of endothelial cells to abnormal physical forces and mechanical stimuli in their local environment. In these conditions, the cellular responses are translated into biochemical signals that induce/aggravate oxidative stress, inflammation, and coagulopathy. Microvascular shear stress-induced alterations could be treated or prevented by the development and use of innovative pharmacologic strategies that effectively target shear-mediated endothelial dysfunction, including shear-responsive drug delivery systems and novel antioxidants, and by targeting the venous side of the circulation to exploit the beneficial antithrombogenic profile of venous endothelial cells.
引用
收藏
页数:23
相关论文
共 12 条
  • [1] Endothelial oxidative stress is correlated with hemorrhagic shock severity in trauma patients
    Laplace, C
    Huet, O
    Vicaut, E
    Benhamou, D
    Duranteau, J
    INTENSIVE CARE MEDICINE, 2003, 29 : S139 - S139
  • [2] Effects of trauma, hemorrhagic shock, and chronic stress on lung vascular endothelial growth factor
    Loftus, Tyler J.
    Thomson, Andrew J.
    Kannan, Kolenkode B.
    Alamo, Ines G.
    Ramos, Harry N.
    Whitley, Elizabeth E.
    Efron, Philip A.
    Mohr, Alicia M.
    JOURNAL OF SURGICAL RESEARCH, 2017, 210 : 15 - 21
  • [3] Haemorragic shock induces endothelial oxidative stress in trauma patients
    Laplace, C
    Huet, O
    Cheisson, G
    Martin, L
    Ract, C
    Edouard, A
    Benhamou, D
    Duranteau, J
    INTENSIVE CARE MEDICINE, 2002, 28 : S35 - S35
  • [4] Complement therapeutic strategies in trauma, hemorrhagic shock and systemic inflammation - closing Pandora's box?
    Huber-Lang, Markus
    Gebhard, Florian
    Schmidt, Christoph Q.
    Palmer, Annette
    Denk, Stephanie
    Wiegner, Rebecca
    SEMINARS IN IMMUNOLOGY, 2016, 28 (03) : 278 - 284
  • [5] Estrogen as a Safe Therapeutic Adjunct in Reducing the Inflammatory Storm in Trauma Hemorrhagic Shock Patients
    Gupta, Dablu Lal
    Tiwari, Shrestha
    Sinha, Tej Prakash
    Soni, Kapil Dev
    Galwankar, Sagar
    Kumar, Subodh
    Rao, D. N.
    Bhoi, Sanjeev
    SHOCK, 2021, 56 (04): : 514 - 521
  • [6] Novel strategies for immunomodulation after trauma: Revisiting hypertonic saline as a resuscitation strategy for hemorrhagic shock
    Rotstein, OD
    JOURNAL OF TRAUMA-INJURY INFECTION AND CRITICAL CARE, 2000, 49 (04): : 580 - 583
  • [7] Prehospital Lyophilized Plasma Transfusion for Trauma-Induced Coagulopathy in Patients at Risk for Hemorrhagic Shock A Randomized Clinical Trial
    Jost, Daniel
    Lemoine, Sabine
    Lemoine, Frederic
    Derkenne, Clement
    Beaume, Sebastien
    Lanoe, Vincent
    Maurin, Olga
    Louis-Delauriere, Emilie
    Delacote, Maelle
    Dang-Minh, Pascal
    Franchin-Frattini, Marilyn
    Bihannic, Rene
    Savary, Dominique
    Levrat, Albrice
    Baudouin, Clemence
    Trichereau, Julie
    Salome, Marina
    Frattini, Benoit
    Ha, Vivien Hong Tuan
    Jouffroy, Romain
    Seguineau, Edouard
    Titreville, Rudy
    Roquet, Florian
    Stibbe, Olivier
    Vivien, Benoit
    Verret, Catherine
    Bignand, Michel
    Travers, Stephane
    Martinaud, Christophe
    Arock, Michel
    Raux, Mathieu
    Prunet, Bertrand
    Ausset, Sylvain
    Sailliol, Anne
    Tourtier, Jean-Pierre
    JAMA NETWORK OPEN, 2022, 5 (07) : E2223619
  • [8] Hypotensive Resuscitation Strategy Reduces Transfusion Requirements and Severe Postoperative Coagulopathy in Trauma Patients With Hemorrhagic Shock: Preliminary Results of a Randomized Controlled Trial
    Morrison, C. Anne
    Carrick, Matthew M.
    Norman, Michael A.
    Scott, Bradford G.
    Welsh, Francis J.
    Tsai, Peter
    Liscum, Kathleen R.
    Wall, Matthew J., Jr.
    Mattox, Kenneth L.
    JOURNAL OF TRAUMA-INJURY INFECTION AND CRITICAL CARE, 2011, 70 (03): : 652 - 663
  • [9] Trauma-hemorrhagic shock-induced pulmonary epithelial and endothelial cell injury utilizes different programmed cell death signaling pathways
    Barlos, Dimtrios
    Deitch, Edwin A.
    Watkins, Anthony C.
    Caputo, Frank J.
    Lu, Qi
    Abungu, Billy
    Colorado, Iriana
    Xu, Da-Zhong
    Feinman, Rena
    AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY, 2009, 296 (03) : L404 - L417
  • [10] The role of oxidant-mediated pathways in the cytotoxicity of endothelial cells exposed to mesenteric lymph from rats subjected to trauma-hemorrhagic shock
    Osband, AJ
    Deitch, EA
    Lu, Q
    Zaets, S
    Dayal, S
    Lukose, B
    Xu, DZ
    SHOCK, 2003, 20 (03): : 269 - 273