In silico Assessment of Biological Activity and Ozonolytic Synthesis of Platanic Acid and Its Derived N-Acylhydrazones

被引：0
|
作者：
Belyaeva, E. R. [1 ]
Ishmuratov, G. Yu. [1 ]
机构：
[1] Russian Acad Sci, Ufa Inst Chem, Special Struct Div Ufa Fed Res Ctr, Ufa 450054, Russia
来源：
RUSSIAN JOURNAL OF GENERAL CHEMISTRY | 2023年 / 93卷 / SUPPL 1期
关键词：
betulinic acid; platanic acid; ozonolysis; carboxylic acid hydrazide; C-20-acylhydrazone; BETULINIC ACID; DERIVATIVES;
D O I：
10.1134/S1070363223140232
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
An efficient low-temperature (-70 degrees C) ozonolytic synthesis of a natural platanic acid from betulinic acid was proposed. The synthesized platanic acid was reacted with monocarboxylic acid hydrazides to obtain a series of novel C-20-acylhydrazones. The online version of the OCHEM expert system was used for in silico assessment of the cytotoxic activity, acute oral toxicity in mice, and hematotoxicity of betulinic and platanic acids and N-acylhydrazones containing a lupane fragment.
引用
收藏
页码：S124 / S130
页数：7
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