Accuracy of VO2 estimation according to the widely used Krakau formula for the prediction of cardiac output

Background: Invasive cardiac output (CO) is measured with the thermodilution (TD) or the indirect Fickmethod (iFM) in right heart catheterization (RHC). The iFMestimates CO using approximation formulas for oxygen consumption (.VO2), but there are significant discrepancies (> 20%) between both methods. Although regularly applied, the formula proposed by Krakau has not been validated. We compared the CO discrepancies between the Krakau formula with the reference (TD) and three established formulas and investigated whether alterations assessed in cardiac magnetic resonance imaging (CMR) determined the extent of the deviations. Methods: This retrospective study included 188 patients aged 63 +/- 14 years (30% women) receiving both CMR and RHC. The CO was measured with TD or with the iFM using the formulas by Krakau, LaFarge, Dehmer, and Bergstra for. VO2 estimation (iFM-K/-L/-D/-B). Percentage errors were calculated as twice the standard deviation of the difference between two CO methods divided by their means; a cut-off of < 30% was regarded as acceptable. The iFMand TD-derived CO ratio was built, and deviations > 20% were counted. Logistic regression analyses were performed to identify determinants of a deviation of > 20%. Results: The TD-derived CO (5.5 +/- 1.7 L/min) was significantly different from all iFM (K: 4.8 +/- 1.6, L: 4.3 +/- 1.6; D: 4.8 +/- 1.5 L/min; B: 5.4 +/- 1.8 L/min all p< 0.05). The iFMK-CO differed from all methods (p< 0.001) except iFM-D (p= 0.19). Percentage errors between TD-CO and iFM-K/-L/-D/-B were all beyond the acceptance limit (44/45/44/43%), while percentage errors between iFM-K and other iFM were all < 16%. None of the parameters measured in CMR was predictive of a discrepancy of > 20% between both methods. Conclusion: The Krakau formula was comparable to other iFM in estimating CO levels, but none showed satisfactory agreement with the TD method. Improved derivation cohorts for. VO2 estimation are needed that better reflect today's patients undergoing RHC.